Mechanical regulation of bone remodeling

• Published in: Bone Research Vol. 10; no. 1; p. 16
• Main Authors: Wang, Lijun, You, Xiuling, Zhang, Lingli, Zhang, Changqing, Zou, Weiguo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.02.2022; Springer Nature B.V; Nature Publishing Group
• Subjects: 631/443/63; 631/443/811; Behavior; Bone density; Bone diseases; Bone marrow; Bone surgery; Extracellular matrix; Gene expression; Homeostasis; Internal Medicine; Mechanical properties; Medicine; Medicine & Public Health; Morphology; Orthopedics; Osteoporosis; Review; Review Article; Shear stress; Stem cells
• ISSN: 2095-4700; 2095-6231
• DOI: 10.1038/s41413-022-00190-4

Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via a balance between bone formation by osteoblasts and resorption by osteoclasts. These opposite processes allow the accommodation of bones to dynamic mechanical forces, altering bone mass in response to changing conditions. Mechanical forces are indispensable for bone homeostasis; skeletal formation, resorption, and adaptation are dependent on mechanical signals, and loss of mechanical stimulation can therefore significantly weaken the bone structure, causing disuse osteoporosis and increasing the risk of fracture. The exact mechanisms by which the body senses and transduces mechanical forces to regulate bone remodeling have long been an active area of study among researchers and clinicians. Such research will lead to a deeper understanding of bone disorders and identify new strategies for skeletal rejuvenation. Here, we will discuss the mechanical properties, mechanosensitive cell populations, and mechanotransducive signaling pathways of the skeletal system.