Advances in cancer pain from bone metastasis

• Published in: Drug design, development and therapy Vol. 9; no. default; pp. 4239 - 4245
• Main Authors: Zhu, Xiao-Cui, Zhang, Jia-Li, Ge, Chen-Tao, Yu, Yuan-Yang, Wang, Pan, Yuan, Ti-Fei, Fu, Cai-Yun
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2015; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Analgesics; Analgesics - therapeutic use; Animal models; Animals; Arthritis; Behavior; Bone cancer; Bone Neoplasms - complications; Bone Neoplasms - secondary; Bones; Breakthrough Pain - diagnosis; Breakthrough Pain - drug therapy; Breakthrough Pain - etiology; Breakthrough Pain - metabolism; Breast cancer; Calcaneus; Cancer; Cancer pain; Cancer therapies; Care and treatment; Complications and side effects; Development and progression; Diffusion of Innovation; Disease Models, Animal; Drug Discovery; Drug therapy; Femur; Humans; Humerus; In vivo methods and tests; Investigations; Malignancy; Metastases; Metastasis; Molecular modelling; Molecular Targeted Therapy; Narcotics; Neurosciences; Pain; Pain Management - trends; Pain Measurement; Pain Perception - drug effects; Pain Threshold - drug effects; Prostate; Quality of Life; Review; Signal Transduction - drug effects; Tibia; Torture; Treatment Outcome; Singapore; cancer pain from bone metastasis; molecular mechanisms; animal models of cancer pain; drug treatment
• ISSN: 1177-8881; 1177-8881
• DOI: 10.2147/DDDT.S87568

With the technological advances in cancer diagnosis and treatment, the survival rates for patients with cancer are prolonged. The issue of figuring out how to improve the life quality of patients with cancer has become increasingly prominent. Pain, especially bone pain, is the most common symptom in malignancy patients, which seriously affects the life quality of patients with cancer. The research of cancer pain has a breakthrough due to the development of the animal models of cancer pain in recent years, such as the animal models of mouse femur, humerus, calcaneus, and rat tibia. The establishment of several kinds of animal models related to cancer pain provides a new platform in vivo to investigate the molecular mechanisms of cancer pain. In this review, we focus on the advances of cancer pain from bone metastasis, the mechanisms involved in cancer pain, and the drug treatment of cancer pain in the animal models.