Sake yeast induces the sleep-promoting effects under the stress-induced acute insomnia in mice

• Published in: Scientific reports Vol. 11; no. 1; p. 20816
• Main Authors: Nishimon, Shohei, Sakai, Noriaki, Nishino, Seiji
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.10.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/1385/1815; 631/378/1385/1817; 631/378/1385/2641; 631/378/1385/519; Adenosine; Animals; Body temperature; Humanities and Social Sciences; Insomnia; Locomotor activity; Male; Mice; Mice, Inbred C57BL; multidisciplinary; NREM sleep; Oral administration; REM sleep; Saccharomyces cerevisiae - metabolism; Science; Science (multidisciplinary); Sleep; Sleep deprivation; Sleep disorders; Sleep Initiation and Maintenance Disorders - therapy; Sleep, REM; Wakefulness; Yeast; Yeast, Dried - metabolism; Yeast, Dried - therapeutic use; Yeasts
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-00271-0

Sleep deprivation induces adverse effects on the health, productivity, and performance. The individuals who could not get enough sleep temporarily experience the symptoms of an induced acute insomnia. This study investigated the efficacy of sake yeast in treatment of acute insomnia in mice. The results of this study showed that sake yeast induced a significant dose-dependent wake reduction, a rapid eye movement (REM) and a non-REM (NREM) sleep enhancement during the first 6 h after the oral administration of sake yeast with locomotor activity and core body temperature decreases under the stressful environment in a new cage. In fact, the wake amounts at 3 h and 6 h were significantly reduced after the oral administration of sake yeast compared with the vehicle. The NREM sleep amounts at 3 h and 6 h significantly increased after the administration of sake yeast compared with the vehicle. The REM amount at 6 h significantly increased after the administration of sake yeast compared with the vehicle, but not at 3 h. The previous study suggested that the sleep-promoting effects of sake yeast could be referred from the activating effect of adenosine A 2A receptor (A 2A R). In summary, the sake yeast is an A 2A R agonist and may induce sleep due to its stress-reducing and anti-anxiety properties. Further verification of the involvement of adenosine in the pathophysiology of insomnia is needed.