Sparse orthogonal population representation of spatial context in the retrosplenial cortex

• Published in: Nature communications Vol. 8; no. 1; pp. 243 - 9
• Main Authors: Mao, Dun, Kandler, Steffen, McNaughton, Bruce L., Bonin, Vincent
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.08.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/1595/1554; 631/378/1595/2618; 631/378/3920; Animal memory; Animals; Calcium; Calcium imaging; Cues; Hippocampus - physiology; Humanities and Social Sciences; Male; Memory; Mice; Mice, Inbred C57BL; multidisciplinary; Navigation behavior; Neuroimaging; Neurons; Neurons - physiology; Science; Science (multidisciplinary); Space Perception; Spatial distribution
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-017-00180-9

Sparse orthogonal coding is a key feature of hippocampal neural activity, which is believed to increase episodic memory capacity and to assist in navigation. Some retrosplenial cortex (RSC) neurons convey distributed spatial and navigational signals, but place-field representations such as observed in the hippocampus have not been reported. Combining cellular Ca 2+ imaging in RSC of mice with a head-fixed locomotion assay, we identified a population of RSC neurons, located predominantly in superficial layers, whose ensemble activity closely resembles that of hippocampal CA1 place cells during the same task. Like CA1 place cells, these RSC neurons fire in sequences during movement, and show narrowly tuned firing fields that form a sparse, orthogonal code correlated with location. RSC ‘place’ cell activity is robust to environmental manipulations, showing partial remapping similar to that observed in CA1. This population code for spatial context may assist the RSC in its role in memory and/or navigation. Neurons in the retrosplenial cortex (RSC) encode spatial and navigational signals. Here the authors use calcium imaging to show that, similar to the hippocampus, RSC neurons also encode place cell-like activity in a sparse orthogonal representation, partially anchored to the allocentric cues on the linear track.