Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population

• Published in: Nature genetics Vol. 44; no. 11; pp. 1222 - 1226
• Main Authors: Hirota, Tomomitsu, Takahashi, Atsushi, Kubo, Michiaki, Tsunoda, Tatsuhiko, Tomita, Kaori, Sakashita, Masafumi, Yamada, Takechiyo, Fujieda, Shigeharu, Tanaka, Shota, Doi, Satoru, Miyatake, Akihiko, Enomoto, Tadao, Nishiyama, Chiharu, Nakano, Nobuhiro, Maeda, Keiko, Okumura, Ko, Ogawa, Hideoki, Ikeda, Shigaku, Noguchi, Emiko, Sakamoto, Tohru, Hizawa, Nobuyuki, Ebe, Koji, Saeki, Hidehisa, Sasaki, Takashi, Ebihara, Tamotsu, Amagai, Masayuki, Takeuchi, Satoshi, Furue, Masutaka, Nakamura, Yusuke, Tamari, Mayumi
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.11.2012; Nature Publishing Group
• Subjects: 631/208/205/2138; 692/699/249/2510/1415; Agriculture; Allergic diseases; Allergies; Animal Genetics and Genomics; Asian Continental Ancestry Group - genetics; Asthma; Atopic dermatitis; Biological and medical sciences; Biomedicine; Cancer Research; Dermatitis; Dermatitis, Atopic - genetics; Disease susceptibility; Eczema; Environmental factors; Fundamental and applied biological sciences. Psychology; Gene Function; Gene mutations; Genealogy; Genetic aspects; Genetic Loci; Genetic Predisposition to Disease; Genetics of eukaryotes. Biological and molecular evolution; Genome-Wide Association Study; Genomes; Health aspects; Human Genetics; Humans; Immunopathology; letter; Medical sciences; Pathogenesis; Polymorphism, Single Nucleotide; Risk factors; Skin allergic diseases. Stinging insect allergies; Skin diseases; Japan; Allergy; Immunopathology; Skin disease; Atopic dermatitis; Identification; Locus; Japanese; Atopy
• ISSN: 1061-4036; 1546-1718; 1546-1718
• DOI: 10.1038/ng.2438

Mayumi Tamari and colleagues report a genome-wide association study for atopic dermatitis, a chronic inflammatory skin disease, in a Japanese population. They identify eight new susceptibility loci for atopic dermatitis and compare their results to those of previous studies in European and Chinese populations. Atopic dermatitis is a common inflammatory skin disease caused by interaction of genetic and environmental factors. On the basis of data from a genome-wide association study (GWAS) and a validation study comprising a total of 3,328 subjects with atopic dermatitis and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci: IL1RL1 - IL18R1 - IL18RAP ( P combined = 8.36 × 10 −18 ), the major histocompatibility complex (MHC) region ( P = 8.38 × 10 −20 ), OR10A3 - NLRP10 ( P = 1.54 × 10 −22 ), GLB1 ( P = 2.77 × 10 −16 ), CCDC80 ( P = 1.56 × 10 −19 ), CARD11 ( P = 7.83 × 10 −9 ), ZNF365 ( P = 5.85 × 10 −20 ) and CYP24A1 - PFDN4 ( P = 1.65 × 10 −8 ). We also replicated the associations of the FLG , C11orf30 , TMEM232 - SLC25A46 , TNFRSF6B - ZGPAT , OVOL1 , ACTL9 and KIF3A - IL13 loci that were previously reported in GWAS of European and Chinese individuals and a meta-analysis of GWAS for atopic dermatitis. These findings advance the understanding of the genetic basis of atopic dermatitis.