Full genome analysis of bovine papillomavirus type 1 derived from a calf with severe cutaneous multiple papillomatosis

• Published in: Journal of Veterinary Medical Science Vol. 80; no. 11; pp. 1691 - 1695
• Main Authors: SHIMAKURA, Hidekatsu, DONG, Jianbao, ZHU, Wei, CHAMBERS, James K., UCHIDA, Kazuyuki, KIRIKI, Kensuke, UEMATSU, Mizuho, GOTO, Yoshitaka, YASUDA, Masahiro, YAMASHITA-KAWANISHI, Nanako, TSUZUKI, Masano, LE, Dung T., HATAMA, Shinichi, HAGA, Takeshi
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.11.2018; Japan Science and Technology Agency; The Japanese Society of Veterinary Science
• Subjects: Antigens; bovine papillomavirus type 1; calf; full genome sequencing; Gastrointestinal tract; Genomes; Nodules; Papilloma; Regulatory sequences; severe papillomatosis; Skin diseases; Virology; bovine papillomavirus type 1; full genome sequencing; calf; severe papillomatosis
• ISSN: 0916-7250; 1347-7439; 1347-7439
• DOI: 10.1292/jvms.18-0289

Severe papillomatosis occasionally causes astasia leading to euthanizing cattle. There are currently a limited number of reports on virologic approach in severe bovine papillomatosis. Here we report a full genome characterization of bovine papillomavirus type 1 (BPV-1) from the case of severe papillomatosis. A calf developed numerous papillomas on the skin and some nodules in the upper gastrointestinal tract at seven months old. The skin lesion was diagnosed as the epithelial papilloma with BPV antigen expression, while the gastrointestinal lesions were diagnosed as the fibropapilloma without BPV antigen. Full genome analysis revealed that BPV-1s detected in all the lesions were exactly the same. Compared with the reference BPV-1 sequence, there was a single nucleotide insertion in the upstream regulatory region.