Impact of Malnutrition on Serum Levels of Pro-inflammatory Cytokines among Plasmodium falciparum Malaria Subjects in Nigeria

• Published in: Annals of African Medicine Vol. 23; no. 3; pp. 379 - 384
• Main Authors: Ajibaye, Olusola, Adaramoye, Victoria Olawunmi, Olalere, Shittu, Ibekpobaoku, Agatha N., Olasope, Mayowa A., Eniafe, Gabriel O., Okanazu, Judith C., Orok, Bassey A., Ojo, Sunday, Olukosi, Yetunde Adeeola, Balogun, Emmanuel Oluwadare
• Format: Journal Article
• Language: English
• Published: India Medknow 01.07.2024; Wolters Kluwer - Medknow; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd
• Edition: 2
• Subjects: Adolescent; Adult; Anopheles; Child; Child, Preschool; Cross-Sectional Studies; Cytokines - blood; Development and progression; Enzyme-Linked Immunosorbent Assay; Ethylenediaminetetraacetic acid; Female; Humans; Immune response; Immunity, Innate; Infant; Interleukin-12 - blood; Interleukin-1beta - blood; Interleukins; Malaria; Malaria, Falciparum - blood; Malaria, Falciparum - complications; Malaria, Falciparum - epidemiology; Malaria, Falciparum - immunology; Male; Malnutrition; Malnutrition - blood; Malnutrition - epidemiology; Middle Aged; Nigeria - epidemiology; Nutritional Status; Original Article; Plasmodium falciparum; Prevalence; Tumor Necrosis Factor-alpha - blood; Tumor necrosis factor-TNF; Young Adult; Nigeria; Lagos Nigeria; TNF- α; malnutrition; Cytokines; necrosis; plasmodium; TNF- α malnutrition; IL-12
• ISSN: 1596-3519; 0975-5764; 0975-5764
• DOI: 10.4103/aam.aam_209_23

Background: Understanding the impact of malnutrition on innate immune response in Plasmodium falciparum (Pf)-infected subjects is critical for malaria control. Aims and Objectives: This study aims to investigate the nutritional status and innate immune response of Pf-infected subjects in Lagos, Nigeria. Materials and Methods: A total of 1183 patients with a history of fever or axillary temperature ≥37°C were screened microscopically for Pf at Ijede General Hospital, Lagos, Nigeria. Malnutrition was determined according to the U.S National Center for Health Statistics (NCHS) as stunting, wasting, or underweight when the Z-score is <−2 in the participants aged <20 years. Serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), and IL-12 were determined by capture ELISA while hematological parameters were measured using an automated hematology system. Results: A total of 384 volunteers were positive for Pf, of which 114 were <20 years with a median age of 10 years. Overall malaria prevalence was 20.89%. The malnutrition rate was 89.5%; 24 (21.05%) were stunted, 30 (26.32%) were underweight, and 48 (42.11%) were wasted. Pro-inflammatory cytokine responses were not affected by the type of malaria. TNF-α was higher in participants <5 years (P = 0.001) and in malnourished patients (P < 0.05). Conclusion: Together, it could be deduced that nutritional status influences Plasmodium falciparum malaria outcomes and progression pattern.