慢性乙型肝炎肝纤维化无创性诊断模型的研究进展

早期诊断慢性乙型肝炎肝纤维化并给予及时抗病毒治疗是减少肝硬化、肝癌等并发症发生的关键。肝活组织检查虽然是诊断肝纤维化的＂金标准＂,但存在操作较复杂、有创和容易产生并发症等缺点,因此无创性诊断模型越来越受到临床重视。回顾了目前国内外已有的慢性乙型肝炎肝纤维化无创性诊断模型,发现虽然研究的模型较多,且有一定诊断价值,但是缺乏统一的认识。未来还需要更多的研究来开发更好的模型,使其能够代替肝活组织检查来评估慢性乙型肝炎肝纤维化并指导抗病毒治疗。...

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Bibliographic Details
Published in临床肝胆病杂志 Vol. 31; no. 8; pp. 1355 - 1359
Main Author 唐情容 何清 唐奇远
Format Journal Article
LanguageChinese
Published 深圳市第三人民医院,广东深圳,518112 2015
Subjects
比例危险度模型
综述
肝炎,乙型,慢性
肝硬化
肝炎,乙型,慢性
肝硬化
review
综述
hepatitis B,chronic
比例危险度模型
liver cirrhosis
proportional hazards models
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Summary:早期诊断慢性乙型肝炎肝纤维化并给予及时抗病毒治疗是减少肝硬化、肝癌等并发症发生的关键。肝活组织检查虽然是诊断肝纤维化的＂金标准＂,但存在操作较复杂、有创和容易产生并发症等缺点,因此无创性诊断模型越来越受到临床重视。回顾了目前国内外已有的慢性乙型肝炎肝纤维化无创性诊断模型,发现虽然研究的模型较多,且有一定诊断价值,但是缺乏统一的认识。未来还需要更多的研究来开发更好的模型,使其能够代替肝活组织检查来评估慢性乙型肝炎肝纤维化并指导抗病毒治疗。
Bibliography:hepatitis B; chronic; liver cirrhosis; proportional hazards models; review
It is vital for reducing the occurrence of complications,such as liver cirrhosis and hepatic carcinoma,to early diagnose liver fibrosis in chronic hepatitis B and intervene in time with antiviral therapy. Although liver biopsy is the ＂ golden standard＂ for the diagnosis of fibrosis,it has certain disadvantages,such as complicated operation,invasion,and occurrence of complications. Therefore,non- invasive diagnosis models have gained more and more attention clinically. In this review,we summarizes the non- invasive diagnosis models for chronic hepatitis B that have been established throughout the world. It is noticed that there are a number of models being studied and each model has a diagnostic value,to some degree,but a lack of consensus exists. The development of more efficient models that can replace liver biopsy still needs further research to assess liver fibrosis in chronic hepatitis B and guide antiviral therapy.
TANG Qingrong, HE
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2015.08.046