叉头样转录因子3与胃癌的研究进展

叉头样转录因子3（forkhead box protein 3,Foxp3）过去被认为是调节性T细胞（regulatory T cell,Treg）的关键转录因子,近来发现其在胃癌细胞中也有表达,这可能是一种新的肿瘤免疫逃逸机制。胃癌患者外周血及微环境中Foxp3蛋白及mRNA的高表达可能涉及到多种信号通路,具有重要的基因调控作用并最终使肿瘤逃逸机体的免疫杀伤,干预其表达可能成为一种有效的免疫治疗手段。...

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Published in复旦学报（医学版） Vol. 38; no. 3; pp. 271 - 274
Main Author 马桂芬（综述） 陈世耀（审校）
Format Journal Article
LanguageChinese
Published 复旦大学附属中山医院消化科,上海,200032 2011
Subjects
免疫逃逸
叉头样转录因子3
胃癌
调节性T细胞
胃癌
免疫逃逸
叉头样转录因子3
调节性T细胞
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Summary:叉头样转录因子3（forkhead box protein 3,Foxp3）过去被认为是调节性T细胞（regulatory T cell,Treg）的关键转录因子,近来发现其在胃癌细胞中也有表达,这可能是一种新的肿瘤免疫逃逸机制。胃癌患者外周血及微环境中Foxp3蛋白及mRNA的高表达可能涉及到多种信号通路,具有重要的基因调控作用并最终使肿瘤逃逸机体的免疫杀伤,干预其表达可能成为一种有效的免疫治疗手段。
Bibliography:gastric cancer; regulatory T cell; forkhead box protein 3; immune escape
MA Gui-fen, CHEN Shi-yao （Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai 200032, China）
31-1885/R
Forkhead box protein 3（Foxp3） is recognized as a key transcriptional factor of regulatory T cell（Treg）,but it has been dectected in gastric cancer cells recently,which may be a new mechanism of tumor immune escape.The overexpression of Foxp3 protein and mRNA in peripheral blood and tumor microenviroment of patients with gastric cancer involves in varietal signal pathways and plays an important role in genetic regulations,which makes the tumor evade the immune killing of normal body.Interventing its exprerssion may become an effective method of immune therapy.
ISSN:1672-8467
DOI:10.3969/j.issn.1672-8467.2011.03.016