钼对小鼠后代醛氧化酶和黄嘌呤氧化酶转录水平的影响
试验选用60只二月龄的清洁级ICR小鼠,随机分成4组,每组10只雌性和5只雄性小白鼠,雌雄分开饲养,饮水中加入不同剂量的钼,分别是空白对照组、低钼组（100 mg.L-1）、中钼组（200 mg.L-1）、高钼组（400mg.L-1）,4周后雌雄合笼饲养。产仔后从每组仔鼠中随机雌性小白鼠30只和15只雄性小白鼠按原分组给予不同剂量的钼,8周后,再从每组中随机选取雌性小白鼠10只和5只雄性小白鼠合笼饲养,待其产仔。如此往复,使小鼠繁殖四代。以第三代（F2代）作为研究对象,应用实时荧光定量PCR的方法测定肝脏AOX和XO的转录水平。结果表明,与对照组相比F2代小鼠AOX和XO的转录水平随钼添加剂量...
Saved in:
| Published in | 东北农业大学学报 Vol. 43; no. 6; pp. 72 - 76 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
河南科技大学动物科技学院,河南洛阳,471003%沈阳农业大学畜牧兽医学院,沈阳,110161%沈阳沈北新区动物卫生管理局,沈阳,110121
2012
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1005-9369 |
| DOI | 10.3969/j.issn.1005-9369.2012.06.016 |
Cover
Loading…
| Abstract | 试验选用60只二月龄的清洁级ICR小鼠,随机分成4组,每组10只雌性和5只雄性小白鼠,雌雄分开饲养,饮水中加入不同剂量的钼,分别是空白对照组、低钼组（100 mg.L-1）、中钼组（200 mg.L-1）、高钼组（400mg.L-1）,4周后雌雄合笼饲养。产仔后从每组仔鼠中随机雌性小白鼠30只和15只雄性小白鼠按原分组给予不同剂量的钼,8周后,再从每组中随机选取雌性小白鼠10只和5只雄性小白鼠合笼饲养,待其产仔。如此往复,使小鼠繁殖四代。以第三代（F2代）作为研究对象,应用实时荧光定量PCR的方法测定肝脏AOX和XO的转录水平。结果表明,与对照组相比F2代小鼠AOX和XO的转录水平随钼添加剂量的增加呈递增趋势,实验组与对照组差异显著（P〈0.05）。可见长期钼暴露可提高小鼠后代AOX和XO的转录水平。 |
|---|---|
| AbstractList | 试验选用60只二月龄的清洁级ICR小鼠,随机分成4组,每组10只雌性和5只雄性小白鼠,雌雄分开饲养,饮水中加入不同剂量的钼,分别是空白对照组、低钼组（100 mg.L-1）、中钼组（200 mg.L-1）、高钼组（400mg.L-1）,4周后雌雄合笼饲养。产仔后从每组仔鼠中随机雌性小白鼠30只和15只雄性小白鼠按原分组给予不同剂量的钼,8周后,再从每组中随机选取雌性小白鼠10只和5只雄性小白鼠合笼饲养,待其产仔。如此往复,使小鼠繁殖四代。以第三代（F2代）作为研究对象,应用实时荧光定量PCR的方法测定肝脏AOX和XO的转录水平。结果表明,与对照组相比F2代小鼠AOX和XO的转录水平随钼添加剂量的增加呈递增趋势,实验组与对照组差异显著（P〈0.05）。可见长期钼暴露可提高小鼠后代AOX和XO的转录水平。 S854; 试验选用60只二月龄的清洁级ICR小鼠,随机分成4组,每组10只雌性和5只雄性小白鼠,雌雄分开饲养,饮水中加入不同剂量的钼,分别是空白对照组、低钼组(100mg·L-1)、中钼组(200mg·L-1)、高钼组(400mg·L-1),4周后雌雄合笼饲养.产仔后从每组仔鼠中随机雌性小白鼠30只和15只雄性小白鼠按原分组给予不同剂量的钼,8周后,再从每组中随机选取雌性小白鼠10只和5只雄性小白鼠合笼饲养,待其产仔.如此往复,使小鼠繁殖四代.以第三代(F2代)作为研究对象,应用实时荧光定量PCR的方法测定肝脏AOX和XO的转录水平.结果表明,与对照组相比F2代小鼠AOX和XO的转录水平随钼添加剂量的增加呈递增趋势,实验组与对照组差异显著(P＜0.05).可见长期钼暴露可提高小鼠后代AOX和XO的转录水平. |
| Author | 张才 王雪莹 李鹏 白刃 陈庭锋 杨自军 |
| AuthorAffiliation | 河南科技大学动物科技学院,河南洛阳471003 沈阳农业大学畜牧兽医学院,沈阳110161 沈阳沈北新区动物卫生管理局,沈阳110121 |
| AuthorAffiliation_xml | – name: 河南科技大学动物科技学院,河南洛阳,471003%沈阳农业大学畜牧兽医学院,沈阳,110161%沈阳沈北新区动物卫生管理局,沈阳,110121 |
| Author_FL | WANG Xueying YANG Zijun LI Peng ZHANG Cai CHEN Tingfeng BAI Ren |
| Author_FL_xml | – sequence: 1 fullname: ZHANG Cai – sequence: 2 fullname: WANG Xueying – sequence: 3 fullname: LI Peng – sequence: 4 fullname: BAI Ren – sequence: 5 fullname: CHEN Tingfeng – sequence: 6 fullname: YANG Zijun |
| Author_xml | – sequence: 1 fullname: 张才 王雪莹 李鹏 白刃 陈庭锋 杨自军 |
| BookMark | eNo9j8tKw0AYhWdRwVr7EIIbF4lzy59kKUWtUHDTfchMk5qiU00Q2311VW8VRXQjKLgRrChCafs2TjVvYaTS1YGPj3M4CyinmipAaJlgk7ngrjbMKEmUSTC2DJeBa1JMqInBxARyKD_j86iYJJHADDizCbHzqJz2Rvp1oPvn6ehBX5x9DR_Tk_tJ_1l3b9LjT93rpsOOvu3qy6cZ_Bm_6PH1pP-hB-_fdx09ftNXp4toLvR3k6D4nwVU3VivlspGZXtzq7RWMSRgMAhQ4QAOHRtkQDElPnZBhNQGAZRakvOAOFhKsAJqOcISLCSESiZrwAm3OSuglWntka9CX9W9RvMwVtmgVxOqXWu1xN91DNnxzF2aunKnqeoHUWbvx9GeH7c9TsF2mEPZL0mwdz4 |
| ClassificationCodes | S854 |
| ContentType | Journal Article |
| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 2RA 92L CQIGP W95 ~WA 2B. 4A8 92I 93N PSX TCJ |
| DOI | 10.3969/j.issn.1005-9369.2012.06.016 |
| DatabaseName | 维普期刊资源整合服务平台 中文科技期刊数据库-CALIS站点 维普中文期刊数据库 中文科技期刊数据库-农业科学 中文科技期刊数据库- 镜像站点 Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| DocumentTitleAlternate | Effect of molybdnum on transcriptional level of aldehyde oxidase and xanthine oxidase in mice |
| DocumentTitle_FL | Effect of molybdnum on transcriptional level of aldehyde oxidase and xanthine oxidase in mice |
| EndPage | 76 |
| ExternalDocumentID | dbnydxxb201206016 42678382 |
| GrantInformation_xml | – fundername: 国家自然科学基金; 河南省教育厅自然科学研究计划项目; 河南科技大学SRTP项目(2009102; 2010244) funderid: (31040081); (2010B230002); 河南科技大学SRTP项目(2009102; 2010244) |
| GroupedDBID | 2RA 92L ALMA_UNASSIGNED_HOLDINGS CDYEO CQIGP W95 ~WA 2B. 4A8 92I 93N PSX TCJ |
| ID | FETCH-LOGICAL-c606-162b860f876ce2021a096bf276b6225c44e180cc65e258b5b3f112c3cd6414743 |
| ISSN | 1005-9369 |
| IngestDate | Thu May 29 04:07:25 EDT 2025 Wed Feb 14 10:45:45 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Keywords | 黄嘌呤氧化酶 肝脏 小鼠 钼 醛氧化酶 |
| Language | Chinese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c606-162b860f876ce2021a096bf276b6225c44e180cc65e258b5b3f112c3cd6414743 |
| Notes | To study the effects of Mo on transcriptional level of aldehyde oxidase（AOX） and aldehyde oxidase（XO） in the progeny of animal, 60 2-month-old ICR mice（male： female=2：1）were selected in the test. After 5 days for acclimatization, they were divided into four groups with 10 female and 5 male in each group. Male and female mice were reared apart. Different concentrations of sodium molybdate were added in water and the mice were divided into control group, low Mo group（100 mg. L^-1）, mid-Mo group （200 mg- L^-1）and high Mo group（400 mg- L^-1）. Male and female were put in the same cage for rearing. After delivery,30 female and 15 male mice were selected from the newborn mice and were fed with Mo as the original groups. After 8 weeks, 10 female and 5 male mice were selected for rearing from the new groups. Littered size to the 4th generation. The 3th generation mice （F2 generation） were chosen as laboratory animals, and the liver were taken and detected for transcriptional level of AOX and XO by the method of fluore |
| PageCount | 5 |
| ParticipantIDs | wanfang_journals_dbnydxxb201206016 chongqing_primary_42678382 |
| PublicationCentury | 2000 |
| PublicationDate | 2012 |
| PublicationDateYYYYMMDD | 2012-01-01 |
| PublicationDate_xml | – year: 2012 text: 2012 |
| PublicationDecade | 2010 |
| PublicationTitle | 东北农业大学学报 |
| PublicationTitleAlternate | Journal of Northeast Agricultural University |
| PublicationTitle_FL | Journal of Northeast Agricultural University |
| PublicationYear | 2012 |
| Publisher | 河南科技大学动物科技学院,河南洛阳,471003%沈阳农业大学畜牧兽医学院,沈阳,110161%沈阳沈北新区动物卫生管理局,沈阳,110121 |
| Publisher_xml | – name: 河南科技大学动物科技学院,河南洛阳,471003%沈阳农业大学畜牧兽医学院,沈阳,110161%沈阳沈北新区动物卫生管理局,沈阳,110121 |
| SSID | ssib036437117 ssib012081041 ssib006567412 ssib001100945 ssib000272666 ssib002263419 ssib051368045 |
| Score | 1.8638853 |
| Snippet | 试验选用60只二月龄的清洁级ICR小鼠,随机分成4组,每组10只雌性和5只雄性小白鼠,雌雄分开饲养,饮水中加入不同剂量的钼,分别是空白对照组、低钼组（100 mg.L-1）、中钼组（200... S854;... |
| SourceID | wanfang chongqing |
| SourceType | Aggregation Database Publisher |
| StartPage | 72 |
| SubjectTerms | 小鼠 肝脏 醛氧化酶 钼 黄嘌呤氧化酶 |
| Title | 钼对小鼠后代醛氧化酶和黄嘌呤氧化酶转录水平的影响 |
| URI | http://lib.cqvip.com/qk/90164A/201206/42678382.html https://d.wanfangdata.com.cn/periodical/dbnydxxb201206016 |
| Volume | 43 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NaxQxFA-1gngRRcXWD4o0p7J1JpPJJMdkPyiCnrZQT8tkdrY9batuofZcPdWviiJ6ERS8CK4oQmn73zjV_S98LzO7nRYp6mXIvrx5eXmZ2fdLJnmPkOlUxR6P4rgSRyqs8CRQlbjtpZXQWht5LAYngeuQt26LuXl-cyFcGDshSruWVnt2Nln_47mS_xlVoMG44inZfxjZkVAgQBnGF64wwnD9qzGmdUUVo6ZK6yHVDWoUFoxHZQOrgK49pCig1GmdU2OoDrBKCqoMrQtk1hHyyCpVwlWBBOHuYkhEOYZK7ijSUaDgU82PvV1SU6PaMUNBhQWzcXJATwNqRFTpQjLwGN9JDqislRGzU1tSVR22kjcnHCWv0q77vNBEQ7uiVBBUaqrD4ZPlWssNAzWgb20GNQH7SOPsCSbSqD9QjJpBLlVz5lOot2w4dqVQZVQEGIMZd6PCHyhdY9NIAZxuhhK0dEIjJz3vgCkvufil9VcfA7diDsSyA8njTBUvStkb5EmJClyRp7k56rECJZTzWCh-diQe9xwyF1jWPxIo3EEPgFWRDCRAj5MMpkeYsqR2Z778NZkdmpb6uIG0BIuZOBTGDzB9xA9grs8AJ3oHMDnAj7ul88ihHwjpufzfI4VPkemiNzeO6wtGMFla7i7eBVzmjsl1O3F3sYTommfJmWIqNqXz9-ocGVtfOk_mBlu72eftrP90sPsue_bkx877waO3-_2P2earwcPv2dbmYGcje72ZPf8wIv7a-5Ttvdzvf8u2v_58s5HtfclePL5Amo16szpXKbKNVBKBuagEs1J4HUAHScoA-cYwubcdFgkrwOclnKe-9JJEhCkLpQ1t0IGpShIkbcF9Djj8IhnvLnfTS2QqUGkYiw4L2lzyNBQxBycOM5d2DNOF1EYTZHJkhNZKHlSmNRzSCXK9sEqr-Ke532rb7oP22ppFQ7r4SZPHSbhMTiNjvk54hYz37q2mVwE59-w195j8BrWTlQE |
| linkProvider | CAB International |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E9%92%BC%E5%AF%B9%E5%B0%8F%E9%BC%A0%E5%90%8E%E4%BB%A3%E9%86%9B%E6%B0%A7%E5%8C%96%E9%85%B6%E5%92%8C%E9%BB%84%E5%98%8C%E5%91%A4%E6%B0%A7%E5%8C%96%E9%85%B6%E8%BD%AC%E5%BD%95%E6%B0%B4%E5%B9%B3%E7%9A%84%E5%BD%B1%E5%93%8D&rft.jtitle=%E4%B8%9C%E5%8C%97%E5%86%9C%E4%B8%9A%E5%A4%A7%E5%AD%A6%E5%AD%A6%E6%8A%A5&rft.au=%E5%BC%A0%E6%89%8D+%E7%8E%8B%E9%9B%AA%E8%8E%B9+%E6%9D%8E%E9%B9%8F+%E7%99%BD%E5%88%83+%E9%99%88%E5%BA%AD%E9%94%8B+%E6%9D%A8%E8%87%AA%E5%86%9B&rft.date=2012&rft.issn=1005-9369&rft.volume=43&rft.issue=6&rft.spage=72&rft.epage=76&rft_id=info:doi/10.3969%2Fj.issn.1005-9369.2012.06.016&rft.externalDocID=42678382 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F90164A%2F90164A.jpg http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fdbnydxxb%2Fdbnydxxb.jpg |