Developmental changes in microglial mobilization are independent of apoptosis in the neonatal mouse hippocampus

Highlights • Microglia are surveilling cells involved in clearance of apoptotic cells. • In mouse hippocampus, the density of apoptotic bodies peaks around postnatal day 4. • Rates of microglial motility and migration correlate with levels of apoptotic debris. • Yet, loss of apoptosis does not alter...

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Published inBrain, behavior, and immunity Vol. 55; pp. 49 - 59
Main Authors Eyo, Ukpong B, Miner, Samuel A, Weiner, Joshua A, Dailey, Michael E
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.07.2016
Subjects
Allergy and Immunology
Animals
Animals, Newborn
Apoptosis
Apoptosis - physiology
Cell Movement - physiology
Hippocampus - cytology
Hippocampus - growth & development
Mice
Microglia
Microglia - cytology
Microglia - physiology
Migration
Mobility
Motility
Psychiatry
Mobility
Motility
Migration
Microglia
Apoptosis
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Summary:Highlights • Microglia are surveilling cells involved in clearance of apoptotic cells. • In mouse hippocampus, the density of apoptotic bodies peaks around postnatal day 4. • Rates of microglial motility and migration correlate with levels of apoptotic debris. • Yet, loss of apoptosis does not alter microglial cell density, motility or migration. • Factors other than apoptosis regulate developmental changes in microglial motility and migration.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Current address: Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2015.11.009