Crystal structure of a bacterial homologue of SWEET transporters

Dear Editor, SWEETs represent a novel family of membrane sugar transporters that have been identified in plants, worms, and mammals. They selectively transport mono- or di- saccharides across plasma or intracellular membranes, and are involved in a number of essential physiologi- cal processes [1]....

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Published inCell research Vol. 24; no. 12; pp. 1486 - 1489
Main Authors Wang, Jing, Yan, Chuangye, Li, Yini, Hirata, Kunio, Yamamoto, Masaki, Yan, Nieng, Hu, Qi
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.12.2014
Subjects
Bacteria
Bacteria - chemistry
Bacterial Proteins - chemistry
Crystallography, X-Ray
Letter to the Editor
Membrane Transport Proteins - chemistry
Models, Molecular
Protein Conformation
同源
哺乳动物
晶体结构
植物
糖果
细胞内
细菌
转运
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Summary:Dear Editor, SWEETs represent a novel family of membrane sugar transporters that have been identified in plants, worms, and mammals. They selectively transport mono- or di- saccharides across plasma or intracellular membranes, and are involved in a number of essential physiologi- cal processes [1]. The functions of SWEETs are best characterized in plants. In Arabidopsis thaliana, AtS- WEET1/4/5/7/8/13 mediate glucose effiux [1], AtS- WEET 11/12 function as sucrose transporters [2], and AtSWEET17 permeates fructose [3, 4]. These SWEETs are important for the growth and development of plants, and some are hijacked by pathogens or symbionts for their own sugar supply.
Bibliography:Dear Editor, SWEETs represent a novel family of membrane sugar transporters that have been identified in plants, worms, and mammals. They selectively transport mono- or di- saccharides across plasma or intracellular membranes, and are involved in a number of essential physiologi- cal processes [1]. The functions of SWEETs are best characterized in plants. In Arabidopsis thaliana, AtS- WEET1/4/5/7/8/13 mediate glucose effiux [1], AtS- WEET 11/12 function as sucrose transporters [2], and AtSWEET17 permeates fructose [3, 4]. These SWEETs are important for the growth and development of plants, and some are hijacked by pathogens or symbionts for their own sugar supply.
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ISSN:1001-0602
1748-7838
DOI:10.1038/cr.2014.144