A New, Convenient Cell-Based Screening Method for Small-Molecule Glycolytic Inhibitors

To counteract active glycolysis in tumors, we developed a new, convenient cell-based screening system to identify an inhibitor of glycolysis. Using this system, we searched for an inhibitor in the synthetic Carbasugar library and found two candidates. It was found that both inhibited glycolysis by s...

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Bibliographic Details
Published inBioscience, biotechnology, and biochemistry Vol. 75; no. 2; pp. 367 - 369
Main Authors KITAGAWA, Mitsuhiro, MISAWA, Mayuko, OGAWA, Seiichiro, TASHIRO, Etsu, IMOTO, Masaya
Format Journal Article
LanguageEnglish
Published Tokyo Japan Society for Bioscience, Biotechnology, and Agrochemistry 2011
Japan Society for Bioscience Biotechnology and Agrochemistry
Oxford University Press
Subjects
Biological and medical sciences
Biological Transport - drug effects
carbasugar library
Cell Line, Tumor
Drug Evaluation, Preclinical - methods
Fundamental and applied biological sciences. Psychology
Glucose - metabolism
glucose uptake inhibitor
Glycolysis - drug effects
Humans
inhibitor screening
Small Molecule Libraries - pharmacology
tumor glycolysis
Screening
carbasugar library
tumor glycolysis
Glycolysis
glucose uptake inhibitor
Tumor
Inhibitor
Glucose
Method
Uptake
inhibitor screening
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Summary:To counteract active glycolysis in tumors, we developed a new, convenient cell-based screening system to identify an inhibitor of glycolysis. Using this system, we searched for an inhibitor in the synthetic Carbasugar library and found two candidates. It was found that both inhibited glycolysis by suppressing the glucose uptake step in tumor cells.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0916-8451
1347-6947
1347-6947
DOI:10.1271/bbb.100693