Aging in nucleus accumbens and its impact on alcohol use disorders

• Published in: Alcohol (Fayetteville, N.Y.) Vol. 107; pp. 73 - 90
• Main Authors: Konar-Nié, Macarena, Guzman-Castillo, Alejandra, Armijo-Weingart, Lorena, Aguayo, Luis Gerardo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2023; Elsevier Limited
• Subjects: Age; Aged; Aging; Alcohol abuse disorders; Alcohol Drinking; Alcohol use; Alcoholism; Animal cognition; Animals; Behavior; Biomedical research; Brain; Brain research; Child development; Cognition; Dopamine; Drinking behavior; Ethanol; Ethanol - pharmacology; Humans; Infant; Limbic system; Memory; Mice; Nervous system; Neurobiology; Neurotransmitters; Nucleus Accumbens; Older people; Physiology; Psychiatric/Mental Health; Rats; Receptors; Short term memory; Young adults; Nucleus accumbens; Aging; Neurotransmitters; Receptors; Limbic system; Alcohol abuse disorders
• ISSN: 0741-8329; 1873-6823; 1873-6823
• DOI: 10.1016/j.alcohol.2022.08.004

Ethanol is one of the most widely consumed drugs in the world and prolonged excessive ethanol intake might lead to alcohol use disorders (AUDs), which are characterized by neuroadaptations in different brain regions, such as in the reward circuitry. In addition, the global population is aging, and it appears that they are increasing their ethanol consumption. Although research involving the effects of alcohol in aging subjects is limited, differential effects have been described. For example, studies in human subjects show that older adults perform worse in tests assessing working memory, attention, and cognition as compared to younger adults. Interestingly, in the field of the neurobiological basis of ethanol actions, there is a significant dichotomy between what we know about the effects of ethanol on neurochemical targets in young animals and how it might affect them in the aging brain. To be able to understand the distinct effects of ethanol in the aging brain, the following questions need to be answered: (1) How does physiological aging impact the function of an ethanol-relevant region (e.g., the nucleus accumbens)? and (2) How does ethanol affect these neurobiological systems in the aged brain? This review discusses the available data to try to understand how aging affects the nucleus accumbens (nAc) and its neurochemical response to alcohol. The data show that there is little information on the effects of ethanol in aged mice and rats, and that many studies had considered 2–3-month-old mice as adults, which needs to be reconsidered since more recent literature defines 6 months as young adults and >18 months as an older mouse. Considering the actual relevance of an aged worldwide population and that this segment is drinking more frequently, it appears at least reasonable to explore how ethanol affects the brain in adult and aged models. •Ethanol is one of the most abused drugs in the world.•Older people exhibit a trend toward increased consumption of ethanol.•Ethanol consumption causes larger sedation and cognitive impairments in the elderly.•The nucleus accumbens exhibits multiple alterations in normal aging.•The response to ethanol in the aging nucleus accumbens has been little studied.