Attenuated orexinergic signaling underlies depression-like responses induced by daytime light deficiency

• Published in: Neuroscience Vol. 272; pp. 252 - 260
• Main Authors: Deats, S.P, Adidharma, W, Lonstein, J.S, Yan, L
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 11.07.2014; Elsevier
• Subjects: Adult and adolescent clinical studies; Animals; Anxiety - metabolism; Anxiety - therapy; Arvicanthis niloticus; Behavior, Animal - physiology; Benzoxazoles - pharmacology; Biological and medical sciences; Circadian Rhythm - physiology; Depression; Depression - metabolism; Depression - therapy; Disease Models, Animal; diurnal grass rats; Fundamental and applied biological sciences. Psychology; Intracellular Signaling Peptides and Proteins - metabolism; Light; Male; Medical sciences; Mood disorders; Motor Activity - physiology; Neurology; Neuropeptides - metabolism; orexin; Orexins; Photoperiod; Phototherapy - methods; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Rats; SB-334867; seasonal affective disorder; Seasonal Affective Disorder - metabolism; Seasonal Affective Disorder - therapy; Signal Transduction - physiology; Urea - analogs & derivatives; Urea - pharmacology; Vertebrates: nervous system and sense organs; immunoreactivity; DRN; VTA; medial prefrontal cortex; bright light:dark; lateral hypothalamus; SB-334867; PFA; OX1R; serotonin; orexin; diurnal grass rats; DMH; seasonal affective disorder; bed nucleus of stria terminalis; FST; dim light:dark; ICC; orexin 1 receptor; ir; immunocytochemistry; OX; dorsal raphe nucleus; SSP; BNST; mPFC; ventral tegmental area; sweet solution preference; SAD; BLD; 5-HT; LH; DLD; perifornical area; dorsomedial hypothalamus; forced swim test; Mood disorder; Rat; Rodentia; Depression; Neuropeptide; Signal transduction; Vertebrata; Mammalia; Animal; Orexin
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2014.04.069

Highlights • In grass rats, a diurnal rodent model of SAD, the abundance of orexin A is affected by lighting conditions. • The abundance of orexin A is associated with depression-like behaviors elicited by light deficiency. • Antagonism of orexin 1 receptor leads to depression- and anxiety-like behaviors in the diurnal grass rats. • Results suggest orexinergic signaling plays a role in light-dependent fluctuations in affective state relevant to SAD.