Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain

Highlights • Upregulated microglial P2Y12 receptors during neuropathic pain promote its progression. • Microglial electrophysiological and morphological activation during neuropathic pain are regulated by the P2Y12 receptor. • Increased microglial tissues surveillance during neuropathic pain is regu...

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Published inBrain, behavior, and immunity Vol. 55; pp. 82 - 92
Main Authors Gu, Nan, Eyo, Ukpong B, Murugan, Madhuvika, Peng, Jiyun, Matta, Sanjana, Dong, Hailong, Wu, Long-Jun
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.07.2016
Subjects
2-Photon imaging
Allergy and Immunology
Animals
Disease Models, Animal
Electrophysiological Phenomena
Electrophysiology
Female
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Microglia
Microglia - metabolism
Microglia - pathology
Microglia - physiology
Microscopy, Fluorescence, Multiphoton
Neuralgia - metabolism
Neuropathic pain
P2Y12 receptor
Peripheral Nerve Injuries - metabolism
Psychiatry
Receptors, Purinergic P2Y12 - deficiency
Receptors, Purinergic P2Y12 - metabolism
Surveillance
P2Y12 receptor
Electrophysiology
Surveillance
2-Photon imaging
Microglia
Neuropathic pain
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Summary:Highlights • Upregulated microglial P2Y12 receptors during neuropathic pain promote its progression. • Microglial electrophysiological and morphological activation during neuropathic pain are regulated by the P2Y12 receptor. • Increased microglial tissues surveillance during neuropathic pain is regulated by the P2Y12 receptor.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
equal contribution
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2015.11.007