Systemic pregabalin attenuates sensorimotor responses and medullary glutamate release in inflammatory tooth pain model

• Published in: Neuroscience Vol. 218; pp. 359 - 366
• Main Authors: Narita, N, Kumar, N, Cherkas, P.S, Chiang, C.Y, Dostrovsky, J.O, Coderre, T.J, Sessle, B.J
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 30.08.2012; Elsevier
• Subjects: Analgesics - pharmacology; Animal models; Animals; Biological and medical sciences; Dental pulp; Dental Pulp - drug effects; Disease Models, Animal; Dorsal horn; Drugs; Electrodes; Electromyography; EMG; Facial Muscles - drug effects; Facial Muscles - physiology; Fundamental and applied biological sciences. Psychology; gamma-Aminobutyric Acid - analogs & derivatives; gamma-Aminobutyric Acid - pharmacology; glutamate release; Glutamic acid; Glutamic Acid - secretion; Inflammation; Inflammation - chemically induced; Inflammation - drug therapy; Inflammation - metabolism; Irritants - toxicity; Jaw; Male; Medulla Oblongata - drug effects; Medulla Oblongata - metabolism; Microdialysis; mineral oil; Molars; Muscles; mustard oil; Mustard Plant - toxicity; Nervous system; Neurology; Neurotransmission; Oil; Pain perception; Plant Oils - toxicity; Pregabalin; Rats; Rats, Sprague-Dawley; sensorimotor behavior; sensorimotor system; Teeth; Tongue; tooth pulp inflammation; Toothache - chemically induced; Toothache - drug therapy; Toothache - metabolism; Vertebrates: nervous system and sense organs; Mm; genioglossus; phosphate-buffered saline; masseter; glutamate release; MDH; mustard oil; SD; standard deviations; analysis of variance; ANOVA; CSF; EMG; HPLC; GG; PBS; anterior digastric; MO; AD; electromyographic; sensorimotor behavior; tooth pulp inflammation; repeated measures; medullary dorsal horn; high performance liquid chromatography; cerebrospinal fluid; PG; pregabalin; RM; Inflammation; Pregabalin; Glutamate; Pain; Excitatory aminoacid; Neurotransmitter; Models; Behavior; Tooth; Release; Dental pulp
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2012.05.016

Highlights ► The Inflammatory irritant mustard oil was applied to the rat molar tooth pulp. ► Pregabalin dose-dependently attenuated orofacial EMG activity evoked by the mustard oil application. ► Pregabalin also attenuated the medullary release of glutamate evoked by the mustard oil application. ► Based on these findings, pregabalin may prove useful clinically in orofacial inflammatory pain states.