Excessive gestational weight gain in the first trimester among women with normal glucose tolerance and resulting neonatal adiposity

• Published in: Journal of perinatology Vol. 36; no. 12; pp. 1034 - 1038
• Main Authors: Josefson, J L, Simons, H, Zeiss, D M, Metzger, B E
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.12.2016; Nature Publishing Group
• Subjects: 631/443/319; Adipose tissue; Adiposity; Adolescent; Adult; Analysis of Variance; Birth Weight; Body composition; Body fat; Body Mass Index; Body weight; Body weight gain; Childhood obesity; Complications and side effects; Diabetes mellitus; Endocrinology; Female; Gestational diabetes; Glucose; Glucose tolerance; Guidelines; Health aspects; Hospitals; Humans; Hyperglycemia; Infant, Newborn; Medicine; Medicine & Public Health; Metabolism; Neonates; Newborn babies; Normal distribution; Obesity; Obstetrics; original-article; Overweight; Pediatric Surgery; Pediatrics; Plethysmography; Practice Guidelines as Topic; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, First - physiology; Pregnant women; Prognosis; Prospective Studies; Risk factors; Self report; Trajectory analysis; Variance analysis; Weight Gain; Womens health; Young Adult; United States; United States > US; Chicago Illinois
• ISSN: 0743-8346; 1476-5543
• DOI: 10.1038/jp.2016.145

Objective: To assess whether weight gain above or below Institute of Medicine (IOM) recommended amounts in an ethnically diverse obstetric population with normal glucose tolerance is associated with differences in neonatal adiposity. Study Design: In this prospective cohort study, healthy women with normal glucose tolerance based on the International Association of Diabetes and Pregnancy Study Groups guidelines were enrolled. Gestational weight at multiple time points were collected. Neonatal adiposity was measured by air displacement plethysmography at 24 to 72 h of life. Analyses included Fisher’s exact test, analysis of variance and a trajectory analysis using a group-based weight gain trajectory model with a censored normal distribution. Results: Overweight and obese women were more likely to exceed IOM weight gain guidelines. Regardless, there was no significant difference in %body fat of neonates born to mothers who either met or exceeded gestational weight gain (GWG) guidelines. GWG timing influenced neonatal anthropometrics: women who gained excessively by the first prenatal visit had neonates with significantly higher birth weight (3.91 vs 3.45 kg, P< 0.001) and %body fat (13.7 vs 10.9%, P =0.0001) compared with women who had steady and moderate GWG. Conclusion: Avoidance of excessive GWG in the first trimester may prevent high amounts of neonatal adiposity.