Role of Th1 and Th17 cells in organ-specific autoimmunity

• Published in: Journal of autoimmunity Vol. 31; no. 3; pp. 252 - 256
• Main Authors: Dardalhon, Valérie, Korn, Thomas, Kuchroo, Vijay K, Anderson, Ana C
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2008
• Subjects: Allergy and Immunology; Animals; Autoimmunity; Cytokines - immunology; Cytokines - metabolism; Humans; IFN-γ; IL-17; Interleukin-17 - immunology; Interleukin-17 - metabolism; Interleukin-23 - immunology; Interleukin-23 - metabolism; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; Th1; Th1 Cells - immunology; Th1 Cells - metabolism; Th17; Th2 Cells - immunology; Th2 Cells - metabolism; Autoimmunity; IFN-γ; Th1; Th17; IL-17

Abstract CD4+ IFN-γ-producing Th1 cells have long been associated with the pathogenesis of many organ-specific autoimmune diseases; however, the observation of disease in mice deficient in molecules involved in Th1 cell differentiation raised the possibility that other effector T cells were responsi...