Role of Th1 and Th17 cells in organ-specific autoimmunity

Abstract CD4+ IFN-γ-producing Th1 cells have long been associated with the pathogenesis of many organ-specific autoimmune diseases; however, the observation of disease in mice deficient in molecules involved in Th1 cell differentiation raised the possibility that other effector T cells were responsi...

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Published inJournal of autoimmunity Vol. 31; no. 3; pp. 252 - 256
Main Authors Dardalhon, Valérie, Korn, Thomas, Kuchroo, Vijay K, Anderson, Ana C
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.11.2008
Subjects
Allergy and Immunology
Animals
Autoimmunity
Cytokines - immunology
Cytokines - metabolism
Humans
IFN-γ
IL-17
Interleukin-17 - immunology
Interleukin-17 - metabolism
Interleukin-23 - immunology
Interleukin-23 - metabolism
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - metabolism
Th1
Th1 Cells - immunology
Th1 Cells - metabolism
Th17
Th2 Cells - immunology
Th2 Cells - metabolism
Autoimmunity
IFN-γ
Th1
Th17
IL-17
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Summary:Abstract CD4+ IFN-γ-producing Th1 cells have long been associated with the pathogenesis of many organ-specific autoimmune diseases; however, the observation of disease in mice deficient in molecules involved in Th1 cell differentiation raised the possibility that other effector T cells were responsible for inducing autoimmunity. Recently, a new CD4+ effector T cell subset that produces IL-17 (Th17) has emerged. The fact that Th17 cells are highly auto-pathogenic has fueled a debate as to what role, if any, Th1 cells play in the induction of tissue inflammation and autoimmune disease. This review will discuss the respective roles of the Th1 and Th17 subsets in organ-specific autoimmunity.
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ISSN:0896-8411
1095-9157
DOI:10.1016/j.jaut.2008.04.017