Late effects after stem cell transplantation (SCT) in children - growth and hormones

Stem cell transplantation (SCT) has established itself as a very successful therapy in often otherwise unbeatable disorders. In a subset of children and adolescents there are, however, late effects, often as a combination of the underlying disorder, its primary treatment and subsequent SCT. In child...

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Published inBone marrow transplantation (Basingstoke) Vol. 35; no. S1; pp. S77 - S81
Main Authors Ranke, M B, Schwarze, C P, Dopfer, R, Klingebiel, T, Scheel-Walter, H-G, Lang, P, Niethammer, D
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.03.2005
Subjects
Adolescent
Adolescents
Bone marrow
Care and treatment
Child
Child, Preschool
Children
Complications and side effects
Diagnosis
Disorders
Endocrine system
Female
Fertility
Growth Disorders - blood
Growth Disorders - etiology
Health aspects
Hormones
Hormones - blood
Humans
Infant
Male
Metabolism, Inborn errors of
Patients
Physicians
Puberty
Puberty - blood
Quality of life
Risk factors
Stem cell transplantation
Stem Cell Transplantation - mortality
Stem cells
Thyroid
Time
Transplantation
Transplantation, Autologous
Germany
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Summary:Stem cell transplantation (SCT) has established itself as a very successful therapy in often otherwise unbeatable disorders. In a subset of children and adolescents there are, however, late effects, often as a combination of the underlying disorder, its primary treatment and subsequent SCT. In children and adolescents, disorders of growth and the endocrine system have been observed to occur frequently. The assurance of normal growth, puberty, fertility and thyroid function--including the prevention of secondary malignancies--is of utmost importance for the overall success of treatment and the maintenance of quality of life. This, however, requires a systematic and structured follow-up programme for patients after SCT. Patients and their families need to be made familiar with this concept early and physicians need to understand that such a system must be implemented as part of a comprehensive care.
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ISSN:0268-3369
1476-5365
DOI:10.1038/sj.bmt.1704853