Circular RNA is enriched and stable in exosomes： a promising biomarker for cancer diagnosis

Circular RNAs （circRNAs） are recently identified as a naturally occurring family of widespread and diverse endogenous noncoding RNAs that may regulate gene expression in mammals . They are unusually sta- ble RNA molecules with cell type- or developmental stage-specific expression patterns . Exosomes...

Full description

Saved in:
Bibliographic Details
Published inCell research Vol. 25; no. 8; pp. 981 - 984
Main Authors Li, Yan, Zheng, Qiupeng, Bao, Chunyang, Li, Shuyi, Guo, Weijie, Zhao, Jiang, Chen, Di, Gu, Jianren, He, Xianghuo, Huang, Shenglin
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.08.2015
Nature Publishing Group
Subjects
631/45/500
631/80
692/53/2421
692/699/67
Animals
Biomarkers, Tumor
Biomedical and Life Sciences
Cell Biology
Early Detection of Cancer - methods
Exosomes - metabolism
Humans
Letter to the Editor
Life Sciences
Neoplasms, Experimental - diagnosis
Neoplasms, Experimental - genetics
RNA - analysis
RNA - genetics
发育阶段特异性
循环
生物标志物
癌症
稳定
细胞类型
诊断
非编码RNA
Online AccessGet full text

Cover

More Information
Summary:Circular RNAs （circRNAs） are recently identified as a naturally occurring family of widespread and diverse endogenous noncoding RNAs that may regulate gene expression in mammals . They are unusually sta- ble RNA molecules with cell type- or developmental stage-specific expression patterns . Exosomes are small membrane vesicles of endocytic origin secreted by most cell types. They contain a specific cargo of protein, mRNA and microRNA species, which can modulate recipient cell behaviors and may be used as biomarkers for diagnosis of human diseases .
Bibliography:31-1568
Circular RNAs （circRNAs） are recently identified as a naturally occurring family of widespread and diverse endogenous noncoding RNAs that may regulate gene expression in mammals . They are unusually sta- ble RNA molecules with cell type- or developmental stage-specific expression patterns . Exosomes are small membrane vesicles of endocytic origin secreted by most cell types. They contain a specific cargo of protein, mRNA and microRNA species, which can modulate recipient cell behaviors and may be used as biomarkers for diagnosis of human diseases .
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
These two authors contributed equally to this work.
ISSN:1001-0602
1748-7838
DOI:10.1038/cr.2015.82