Towards an HIV-1 cure: measuring the latent reservoir

Highlights • A high-throughput and well-validated assay is needed to accurately measure the HIV-1 LR. • PCR-based assays overestimate the size of the LR. • Culture-based assays underestimate the size of the LR. • No two HIV-1 eradication clinical trials use the same measurement.

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Bibliographic Details
Published inTrends in microbiology (Regular ed.) Vol. 23; no. 4; pp. 192 - 203
Main Authors Bruner, Katherine M, Hosmane, Nina N, Siliciano, Robert F
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2015
Subjects
assays
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - virology
cure
Disease Reservoirs - virology
HIV Infections - therapy
HIV Infections - virology
HIV-1
HIV-1 - physiology
Humans
Internal Medicine
latency
Lymphocyte Activation
Polymerase Chain Reaction
Proviruses - physiology
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - virology
Viral Load
Virus Latency
HIV-1
assays
cure
latency
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Summary:Highlights • A high-throughput and well-validated assay is needed to accurately measure the HIV-1 LR. • PCR-based assays overestimate the size of the LR. • Culture-based assays underestimate the size of the LR. • No two HIV-1 eradication clinical trials use the same measurement.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-2
ObjectType-Feature-2
Denotes equal contribution.
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2015.01.013