The effect of recombinant human epidermal growth factor on radiation dermatitis in rectal and anal cancer patients: a self-controlled study

• Published in: BMC cancer Vol. 22; no. 1; pp. 1 - 1140
• Main Authors: Liu, Shuai, Wang, Yun-Long, Shi, Shu-Ting, Zeng, Guang-Dong, Song, Yi-Wen, Zhang, Xiao-Dong, Zheng, Jian, Fan, Xin-Juan, Liu, Yan-Ping
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 05.11.2022; BioMed Central; BMC
• Subjects: Anal cancer; Analysis; Anus; Cancer; Cancer patients; Cancer therapies; Care and treatment; Chemotherapy; Chi-square test; Clinical trial; Colorectal cancer; Complications and side effects; Dermatitis; Edema; Epidermal growth factor; Internalization; Ostomy; Patients; Physiology; Radiation dermatitis; Radiation therapy; Radioresistance; Radiotherapy; Rectal and anal cancer; Rectum; rhEGF; Skin; Statistical analysis; Tumors; China; Monaco
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-022-10226-x

Background Our previous study reported that recombinant human epidermal growth factor (rhEGF)-triggered EGFR internalization promoted radioresistance. Here, we aimed to evaluate the effect of rhEGF on the skin protection of rectal and anal cancer patients receiving radiotherapy. Methods One hundred and ninety-three rectal and anal cancer patients who received radiotherapy were prospectively enrolled from January 2019 to December 2020. To perform self-controlled study, the left and right pelvic skin area (separated by midline) were randomly assigned to the rhEGF and control side. The association between radiation dermatitis and factors including rhEGF, the dose of radiotherapy and tumor distance from anal edge were analyzed. Results Among 193 enrolled patients, 41 patients (21.2%) did not develop radiation dermatitis, and 152 patients (78.8%) suffered radiation dermatitis on at least one side of pelvic skin at the end of radiotherapy. For the effect on radiation dermatitis grade, rhEGF had improved effect on 6 (4.0%) patients, detrimental effect on 2 (1.3%) patients, and no effect on 144 (94.7%) patients. Whereas for the effect on radiation dermatitis area, rhEGF showed improved effect on the radiation dermatitis area of 46 (30.2%) patients, detrimental effect on 15 (9.9%) patients, and no effect on 91 (59.9%) patients. The radiation dermatitis area of rhEGF side was significantly smaller than that of control side (P = 0.0007). Conclusions rhEGF is a skin protective reagent for rectal and anal cancer patients receiving radiotherapy. Trial registration Chinese Clinical Trial Registry identifier: ChiCTR1900020842; Date of registration: 20/01/2019. Keywords: rhEGF, Radiation dermatitis, Rectal and anal cancer, Clinical trial