Regulation of lipid metabolism: a tale of two yeasts

Eukaryotic cells synthesize multiple classes of lipids by distinct metabolic pathways in order to generate membranes with optimal physical and chemical properties. As a result, complex regulatory networks are required in all organisms to maintain lipid and membrane homeostasis as well as to rapidly...

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Bibliographic Details
Published inCurrent opinion in cell biology Vol. 24; no. 4; pp. 502 - 508
Main Authors Raychaudhuri, Sumana, Young, Barry P, Espenshade, Peter J, Loewen, Christopher JR
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2012
Subjects
Environmental stress
Homeostasis
Internal Medicine
Lipid metabolism
Lipid Metabolism - physiology
Lipids
Metabolic pathways
Protein folding
Reviews
Saccharomyces cerevisiae - metabolism
Schizosaccharomyces - metabolism
Schizosaccharomyces pombe
Signal transduction
Signal Transduction - physiology
Unfolded Protein Response - physiology
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Summary:Eukaryotic cells synthesize multiple classes of lipids by distinct metabolic pathways in order to generate membranes with optimal physical and chemical properties. As a result, complex regulatory networks are required in all organisms to maintain lipid and membrane homeostasis as well as to rapidly and efficiently respond to cellular stress. The unicellular nature of yeast makes it particularly vulnerable to environmental stress and yeast has evolved elaborate signaling pathways to maintain lipid homeostasis. In this article we highlight the recent advances that have been made using the budding and fission yeasts and we discuss potential roles for the unfolded protein response (UPR) and the SREBP-Scap pathways in coordinate regulation of multiple lipid classes.
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These authors contributed equally to this work
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2012.05.006