Human innate lymphoid cells

• Published in: Journal of allergy and clinical immunology Vol. 138; no. 5; pp. 1265 - 1276
• Main Authors: Mjösberg, Jenny, Spits, Hergen
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2016; Elsevier Limited
• Subjects: allergy; Allergy and Immunology; Animals; asthma; Cytokines; Disease; graft-versus-host disease; Human subjects; Humans; Immunity, Innate; Inflammation; inflammatory bowel disease; Innate lymphoid cells; Lymphocytes - classification; Lymphocytes - immunology; mucosal immunity; psoriasis; Transcription factors; tumor immunity; FLG; Nrp1; ILC; LN; ART; LP; CLP; Innate lymphoid cells; LT; CRSwNP; GVHD; γc; ILC2; ILC3; ieILC1; ILC1; TLR; HSCT; mucosal immunity; KLRG1; LTi; cNK; AD; Nfil3; TSLP; IL1R1; allergy; asthma; tumor immunity; IL-2R; inflammatory bowel disease; ROR; psoriasis; CRTH2; NK; graft-versus-host disease; COPD; DC; PP; PS; cNK cell; cluster of differentiation; EILP; atopic dermatitis; MHC; innate lymphoid cells; major histocompatibility complex; PLZF; TNF; TNF-like ligand 1A; GM-CSF; chemoattractant receptor-homologous molecule expressed on Th2; Toll-like receptor; IL; inhibitor of DNA binding; RA; intestinal stem cell; lamina propria; human immunodeficiency virus; Id; TOX; fat-associated lymphoid tissue; BCL11b; conventional natural killer cell; B-Cell CLL/Lymphoma 11B; IBD; GATA3; Thymocyte Selection Associated High Mobility Group Box; simian immunodeficiency virus; FALC; ISC; Peyer’s patch; CD; LMPP; GvHD; lymphoid tissue organizer; thymic stromal lymphopoetin; lymphoid-primed multipotent progenitors; HIV; tumor necrosis factor; vascular cell adhesion molecule; Neuropilin 1; NRP1; TL1A; cutaneous lymphocyte antigen; prostaglandin E2; chronic rhinosinusitis with nasal polyps; lipoxin A4; hematopoetic stem cell transfer; lymphoid tissue inducer; Tbet; recombinase activating gene; AML; janus kinase; chemokine receptor; VCAM; retinoic acid; Nuclear Factor, Interleukin 3 Regulated; Intracellular adhesion molecule; TCF; T-box protein expressed in T cells; granulocyte-macrophage colony-stimulating factor; LXA4; Promyelocytic Leukemia Zinc Finger; SIV; GALT; antiretroviral therapy; LTO; common helper innate lymphoid cell progenitor; IFN; retinoic acid-related orphan receptor; acute myeloid leukemia; GATA3 binding protein 3; T cell factor; CHILP; interleukin; Innate lymphoid cells (ILC); PGE2; intraepithelial ILC1; stem cell factor; ICAM; Killer cell lectin-like receptor subfamily G member 1; early innate lymphoid progenitor; chronic obstructive pulmonary disorder; interferon; BAL; CCR; JAK; lymph node; SCF; gut-associated lymphoid tissue; CLA; RAG; bronchoalveolar lavage; common lymphocyte progenitor

Innate lymphoid cells (ILCs) are increasingly acknowledged as important mediators of immune homeostasis and pathology. ILCs act as early orchestrators of immunity, responding to epithelium-derived signals by expressing an array of cytokines and cell-surface receptors, which shape subsequent immune r...