Caries-related saliva properties in individuals with 22q11 deletion syndrome

• Published in: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics Vol. 103; no. 4; pp. 497 - 504
• Main Authors: Klingberg, Gunilla, Lingström, Peter, Óskarsdóttir, Sólveig, Friman, Vanda, Bohman, Eva, Carlén, Anette
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01.04.2007
• Subjects: Adolescent; Adult; analysis; blood; Case-Control Studies; chemistry; Child; Child, Preschool; Chromosome Deletion; Chromosomes; Chromosomes, Human, Pair 22 - genetics; Clinical Medicine; Dental Caries; Dental Caries - blood; Dental Caries - microbiology; Dentistry; Female; genetics; Human; Humans; Immunoglobulin A; Immunoglobulin A - analysis; Klinisk medicin; Male; Medical and Health Sciences; Medicin och hälsovetenskap; microbiology; Nonparametric; Odontologi; Odontology; Pair 22; Preschool; Saliva; Saliva - chemistry; Saliva - secretion; Salivary Proteins and Peptides; Salivary Proteins and Peptides - analysis; Salivation; secretion; Statistics; Statistics, Nonparametric; Surgery; Syndrome
• ISSN: 1079-2104; 1528-395X; 2212-4411; 1528-395X
• DOI: 10.1016/j.tripleo.2006.09.018

The aims were to compare saliva secretion rate, buffer capacity, cariogenic bacteria, total protein, IgA, and electrolytes between patients with 22q11 deletion syndrome (22q11DS) and control subjects and to study correlations between saliva and serum levels of IgA and electrolytes in 22q11DS patients. Twenty-nine consecutive 22q11DS patients (mean age 12.6 years) and matched healthy control subjects were clinically examined, and stimulated saliva samples were collected. Patients with 22q11DS had impaired salivary secretion rate ( P < .01) and buffer capacity ( P < .05), higher numbers of cariogenic bacteria ( P < .01), increased saliva protein concentrations ( P < .001), and reduced output of electrolytes ( P < .001–.05) compared with control subjects. A correlation between concentration in serum and saliva was found only for IgA (r = .622; P < .01). Different salivary components were affected in patients with 22q11DS, which may explain the increased caries risk seen in these patients.