Four New Lignans from Viburnum foetidum var. foedidum

The 70% aqueous acetone extract of the aerial part of Viburnum foetidum var. foedidum afforded four new lignans (1—4) together with six known ones. The structures of the four new compounds were elucidated on the basis of 1D (dimensional), 2D-NMR, and mass spectral analysis. The structure of compound...

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Published inChemical & pharmaceutical bulletin Vol. 57; no. 10; pp. 1129 - 1131
Main Authors Chen, Xuan-Qin, Li, Yan, He, Juan, Wang, Kou, Li, Ming-Ming, Pan, Zheng-Hong, Peng, Li-Yan, Cheng, Xiao, Zhao, Qin-Shi
Format Journal Article
LanguageEnglish
Published TOKYO The Pharmaceutical Society of Japan 01.10.2009
Pharmaceutical Soc Japan
Japan Science and Technology Agency
Subjects
Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
Crystallography, X-Ray
Life Sciences & Biomedicine
lignan
Lignans - chemistry
Lignans - isolation & purification
Magnetic Resonance Spectroscopy
Molecular Conformation
Pharmacology & Pharmacy
Physical Sciences
Plant Extracts - chemistry
Science & Technology
Viburnum - chemistry
Viburnum foetidum var. foedidum
X-ray diffraction analysis
DITERPENES
lignan
TRITERPENES
Viburnum foetidum var. foedidum
X-ray diffraction analysis
CONSTITUENTS
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Summary:The 70% aqueous acetone extract of the aerial part of Viburnum foetidum var. foedidum afforded four new lignans (1—4) together with six known ones. The structures of the four new compounds were elucidated on the basis of 1D (dimensional), 2D-NMR, and mass spectral analysis. The structure of compound 1, with a novel spirocyclic moiety, was also confirmed by X-ray diffraction analysis. Compounds 1—10 were evaluated for their cytotoxic activity. However, none of the compounds showed significant cytotoxic activity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.57.1129