HBV天然免疫的研究进展

R512.62; HBV入侵人体时,天然免疫首先发挥重要的作用.成人感染HBV后,常常会被自发清除,然而在出生或者年幼时期感染HBV时,病情更容易慢性化并且迁延终生.在HBV感染初期,天然免疫应答对病毒复制的抑制发挥了重要作用,HBV感染的转归取决于宿主和病毒共同作用.简述了近年来有关HBV与宿主天然免疫中发挥重要作用的细胞类型、细胞因子、信号通路及其作用机制的研究进展,并指出了其在临床治疗方面的潜在价值....

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Published in临床肝胆病杂志 Vol. 32; no. 5; pp. 992 - 996
Main Author 李凤莉 华娟 卢银平 杨东亮
Format Journal Article
LanguageChinese
Published 华中科技大学同济医学院附属协和医院感染科,感染病与免疫研究所,武汉430022 2016
Subjects
免疫,天然
综述
肝炎病毒,乙型
immunity,natural
综述
肝炎病毒,乙型
hepatitis B virus
review
免疫,天然
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ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2016.05.044

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Summary:R512.62; HBV入侵人体时,天然免疫首先发挥重要的作用.成人感染HBV后,常常会被自发清除,然而在出生或者年幼时期感染HBV时,病情更容易慢性化并且迁延终生.在HBV感染初期,天然免疫应答对病毒复制的抑制发挥了重要作用,HBV感染的转归取决于宿主和病毒共同作用.简述了近年来有关HBV与宿主天然免疫中发挥重要作用的细胞类型、细胞因子、信号通路及其作用机制的研究进展,并指出了其在临床治疗方面的潜在价值.
Bibliography:hepatitis B virus; immunity; natural; review
When hepatitis B virus（ HBV） invades the human body,innate immunity acts the earliest and plays an important role. When an adult is infected with HBV,HBV can often be eliminated spontaneously. However,if HBV infection occurs right after birth or when the patient is young,the disease tends to become chronic and affect the whole life. In the incipient stage of HBV infection,innate immune response plays an important role in inhibiting viral replication,and the prognosis of HBV infection depends on the combined effect of host and virus. This article briefly introduces the research advances in the cells,cytokines,and signaling pathways that play important roles in the host＇s innate immunity against HBV and their mechanisms of action,and points out their potential values in clinical treatment.
LI Fengli, HUA Juan, LU Yinping, et al. （ Department of Infectious Diseases, Institute of Infection and Immunity, Union Hospital of Tongji Medical College, Huazhong University of Sci
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2016.05.044