Elevated Serum Surfactant Protein A and D in a Case of Acute Eosinophilic Pneumonia

• Published in: Internal Medicine Vol. 43; no. 5; pp. 423 - 426
• Main Authors: FUJII, Masaru, TANAKA, Hiroshi, KAMEDA, Masami, FUJII, Masanori, TANAKA, Shintaro, OHASHI, Kensuke, CHIBA, Hirofumi, TAKAHASHI, Hiroki, ABE, Shosaku
• Format: Journal Article
• Language: English
• Published: Tokyo The Japanese Society of Internal Medicine 01.05.2004; Japanese Society of Internal Medicine
• Subjects: Acute Disease; acute eosinophilic pneumonia; Adult; Biological and medical sciences; Biomarkers - blood; Bronchoalveolar Lavage Fluid - cytology; Follow-Up Studies; General aspects; Humans; Male; Medical sciences; Pulmonary Eosinophilia - blood; Pulmonary Eosinophilia - diagnosis; Pulmonary Eosinophilia - drug therapy; Pulmonary Surfactant-Associated Protein A - blood; Pulmonary Surfactant-Associated Protein D - blood; Pulmonary Surfactants - blood; Radiography, Thoracic; Risk Assessment; Severity of Illness Index; Steroids - therapeutic use; surfactant protein A; surfactant protein D; Tomography, X-Ray Computed; Treatment Outcome; Medicine; Lung disease; surfactant protein A; Pulmonary surfactant; Respiratory disease; Acute; Eosinophilic pneumonia; Surfactant; Serum protein; acute eosinophilic pneumonia; surfactant protein D
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.43.423

A 29-year-old man was admitted to our hospital because of fever elevation, dry cough, malaise, skin eruption, and dyspnea with hypoxemia. His serum levels of surfactant protein (SP) -A and SP-D were markedly high, but serum KL-6 was not. He was diagnosed as acute eosinophilic pneumonia (AEP) on the basis of CT imaging, bronchoalveolar lavage findings and the clinical course. He showed good response to steroid therapy and serum levels of SP-A and SP-D returned to almost normal levels. Our experience suggested that serum SP-A and SP-D might be helpful markers for monitoring the clinical course in AEP.