Pattern Recognition Receptor-Mediated Chronic Inflammation in the Development and Progression of Obesity-Related Metabolic Diseases

• Published in: Mediators of inflammation Vol. 2019; no. 2019; pp. 1 - 14
• Main Authors: Feng, Zhiwei, Song, Xiangfeng, Yang, Yun, Zhang, Hanxiao, Zhao, Weidong, Du, Cancan, Li, Yanhua, Yu, Lili, Sun, Aiping
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2019; Hindawi; Hindawi Limited; Wiley
• Subjects: Animals; Arteriosclerosis; Atherosclerosis; B cells; Chronic Disease; Chronic illnesses; Development and progression; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - metabolism; Diseases; Epidemiology; Fatty liver; Health aspects; Humans; Inflammation - metabolism; Insulin; Insulin resistance; Liver; Liver diseases; Metabolic Diseases - metabolism; Metabolic Diseases - pathology; Metabolic disorders; Metabolites; Obesity; Obesity - metabolism; Obesity - pathology; Oligomerization; Pattern recognition receptors; Review; Toll-like receptors; Type 2 diabetes
• ISSN: 0962-9351; 1466-1861
• DOI: 10.1155/2019/5271295

Obesity-induced chronic inflammation is known to promote the development of many metabolic diseases, especially insulin resistance, type 2 diabetes mellitus, nonalcoholic fatty liver disease, and atherosclerosis. Pattern recognition receptor-mediated inflammation is an important determinant for the initiation and progression of these metabolic diseases. Here, we review the major features of the current understanding with respect to obesity-related chronic inflammation in metabolic tissues, focus on Toll-like receptors and nucleotide-binding oligomerization domain-like receptors with an emphasis on how these receptors determine metabolic disease progression, and provide a summary on the development and progress of PRR antagonists for therapeutic intervention.