Cost-effectiveness of self-managed versus physician-managed oral anticoagulation therapy

• Published in: Canadian Medical Association journal (CMAJ) Vol. 174; no. 13; pp. 1847 - 1852
• Main Authors: Regier, Dean A, Sunderji, Rubina, Lynd, Larry D, Gin, Kenneth, Marra, Carlo A
• Format: Journal Article
• Language: English
• Published: Canada CMA Impact Inc 20.06.2006; CMA Impact, Inc; Canadian Medical Association
• Subjects: Administration, Oral; Analysis; Anticoagulants (Medicine); Anticoagulants - administration & dosage; Anticoagulants - adverse effects; Anticoagulants - economics; Atrial Fibrillation - drug therapy; Atrial Fibrillation - economics; Bayes Theorem; Bayesian analysis; Canada; Cardiovascular disease; Cost of Illness; Cost-Benefit Analysis; Drug therapy; Economic aspects; Effectiveness studies; Health Services Research; Heart Valve Prosthesis - economics; Humans; International Normalized Ratio; Long term health care; Markov analysis; Markov Chains; Medical treatment; National Health Programs; Outcome Assessment, Health Care; Patients; Physician's Role; Physicians; Prices and rates; Quality-Adjusted Life Years; Self Administration - economics; Canada
• ISSN: 0820-3946; 1488-2329
• DOI: 10.1503/cmaj.051104

Patient self-management of long-term oral anticoagulation therapy is an effective strategy in a number of clinical situations, but it is currently not a funded option in the Canadian health care system. We sought to compare the incremental cost and health benefits of self-management with those of physician management from the perspective of the Canadian health care payer over a 5-year period. We developed a Bayesian Markov model comparing the costs and quality-adjusted life years (QALYs) accrued to patients receiving oral anticoagulation therapy through self-management or physician management for atrial fibrillation or for a mechanical heart valve. Five health states were defined: no events, minor hemorrhagic events, major hemorrhagic events, thrombotic events and death. Data from published literature were used for transition probabilities. Canadian 2003 costs were used, and utility estimates were obtained from various published sources. Self-management resulted in 3.50 fewer thrombotic events, 0.78 fewer major hemorrhagic events and 0.12 fewer deaths per 100 patients than physician management. The average discounted incremental cost of self-management over physician management was found to be 989 dollars (95% confidence interval [CI] 310 dollars-1655 dollars) per patient and the incremental QALYs gained was 0.07 (95% CI 0.06-0.08). The cost-effectiveness of self-management was 14,129 dollars per QALY gained. There was a 95% chance that self-management would be cost-effective at a willingness to pay of 23,800 dollars per QALY. Results were robust in probabilistic and deterministic sensitivity analyses. This model suggests that self-management is a cost-effective strategy for those receiving long-term oral anticoagulation therapy for atrial fibrillation or for a mechanical heart valve.