Association of Circulating Omentin-1 with Osteoporosis in a Chinese Type 2 Diabetic Population

• Published in: Mediators of inflammation Vol. 2020; no. 2020; pp. 1 - 16
• Main Authors: Wan, Qin, Miao, Ying, Zhu, Jianhua, Zhang, Zhihong, Xu, Yong, Yan, Pijun, Gao, Chenlin
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; John Wiley & Sons, Inc; Wiley
• Subjects: Absorptiometry, Photon; Aged; Aged, 80 and over; Anthropometry; Apolipoprotein A; Apolipoproteins; Arthritis; Asians; Biomarkers - blood; Blood pressure; Body mass index; Bone and Bones - metabolism; Bone Density; Bone Diseases, Metabolic; Bone mineral density; Bone turnover; Cardiovascular disease; China - epidemiology; Cholesterol; Chronic obstructive pulmonary disease; Creatinine; Cross-Sectional Studies; Cytokines - blood; Development and progression; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetic nephropathies; Diabetic nephropathy; Diabetic retinopathy; Female; Fractures; Glucose; Glycosylated hemoglobin; GPI-Linked Proteins - blood; Hemoglobin; Humans; Hypertension; Inflammation; Inflammatory diseases; Insulin; Lectins - blood; Linear Models; Male; Metabolism; Middle Aged; Multivariate Analysis; Nephropathy; Neutrophils; Osteopenia; Osteoporosis; Osteoporosis - blood; Osteoporosis - complications; Pathogenesis; Phosphatase; Physiological aspects; Plasma; Retinopathy; ROC Curve; Self-assessment; Tartrate-Resistant Acid Phosphatase - metabolism; Type 2 diabetes; Womens health; China; Taiwan
• ISSN: 0962-9351; 1466-1861; 1466-1861
• DOI: 10.1155/2020/9389720

Aims. Omentin-1, a newly identified adipokine, has been demonstrated to be associated with bone metabolism, but the results have been inconsistent. Moreover, the potential relationship of circulating omentin-1 with diabetic osteoporosis has never been reported. This study is intended for studying the association between circulating omentin-1, bone mineral density (BMD), prior fragility fractures, and other bone metabolic-related parameters. Methods. Circulating omentin-1 levels were measured in 172 patients with type 2 diabetes mellitus (T2DM), and participants were divided into the normal BMD group (n=52), the osteopenia group (n=66), and the osteoporosis group (n=54). The relationship between circulating omentin-1 and diabetic osteoporosis and other parameters was analyzed. Results. Circulating omentin-1 was significantly higher in the osteoporosis group than in the normal group and in the osteopenia group (both P<0.05). Circulating omentin-1 levels were correlated significantly and positively with sex; high-density lipoprotein cholesterol; apolipoprotein A; and prevalence of prior fragility fractures, diabetic nephropathy, and retinopathy; they were correlated negatively with diastolic blood pressure, triglyceride, hemoglobin, atherogenic index of plasma, osteoporosis self-assessment tool for Asians, BMD at different skeletal sites, and corresponding T scores, irrespective of age, sex, and body mass index (P<0.01 or P<0.05). Moreover, circulating omentin-1 was an independent decisive factor for the presence of osteoporosis only in women after multivariate adjustment (odds ratio: 1.069; 95% confidence interval: 1.003-1.139; P<0.05). Lastly, the analysis of receiver operating characteristic curves revealed that the best cutoff value for circulating omentin-1 to predict diabetic osteoporosis was 15.37 ng/mL (sensitivity: 71.7%; specificity: 58.5%) in female subjects. Conclusions. High levels of circulating omentin-1 may be associated with the development of osteoporosis in female diabetic subjects and may be a potential biomarker for diabetic osteoporosis in women.