Innate generation of thrombin and intracellular oxidants in airway epithelium by allergen Der p 1

[...]an irreversible inhibitor of serine proteases had no effect on ROS production and purified Der p 2 conspicuously failed to elicit ROS generation (see Fig E2, A and B, in this article's Online Repository at www.jacionline.org). [...]among natural HDM allergens, the initiators of intracellul...

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Published inJournal of allergy and clinical immunology Vol. 138; no. 4; pp. 1224 - 1227
Main Authors Zhang, Jihui, PhD, Chen, Jie, MSc, MB, BS, Allen-Philbey, Kimberley, BSc, Perera Baruhupolage, Chathuri, BSc, Tachie-Menson, Theresa, BSc, Mangat, Shannon C., BSc, Garrod, David R., PhD, Robinson, Clive, PhD
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.10.2016
Elsevier Limited
Mosby
Subjects
Allergens - administration & dosage
Allergies
Allergy and Immunology
Antigens, Dermatophagoides - administration & dosage
Arthropod Proteins - administration & dosage
Asthma
Cell Line
Cells, Cultured
Cysteine Endopeptidases - administration & dosage
Humans
Immunity, Innate - physiology
Letter to the Editor
Reactive Oxygen Species - metabolism
Receptor, PAR-1 - metabolism
Receptors, Thrombin - metabolism
Respiratory Mucosa - cytology
Respiratory Mucosa - immunology
Respiratory Mucosa - metabolism
Rodents
Thrombin - biosynthesis
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Summary:[...]an irreversible inhibitor of serine proteases had no effect on ROS production and purified Der p 2 conspicuously failed to elicit ROS generation (see Fig E2, A and B, in this article's Online Repository at www.jacionline.org). [...]among natural HDM allergens, the initiators of intracellular ROS generation are the group 1 cysteine proteases.
Bibliography:SourceType-Other Sources-1
ObjectType-Article-2
content type line 63
ObjectType-Correspondence-1
Jihui Zhang is currently at State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
These authors contributed equally to this work.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2016.05.006