MALE-SPECIFIC METABOLISM OF SIMVASTATIN BY RAT LIVER MICROSOMES

Simvastatin was more effectively metabolized by the liver microsomes of male rats than females. The sex difference appeared in the composition of the metabolites. Two male-specific metabolites were identified by NMR and mass spectrometry as 3"-hydroxy and 3', 3"-dihydroxy-Δ4', 5&...

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Published inChemical & pharmaceutical bulletin Vol. 39; no. 1; pp. 236 - 238
Main Authors UCHIYAMA, Naotaka, KAGAMI, Yayoi, SAITOH, Yuko, OHTAWA, Masakatsu
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 01.01.1991
Maruzen
Subjects
Animals
Biological and medical sciences
Female
General and cellular metabolism. Vitamins
Hydroxymethylglutaryl-CoA Reductase Inhibitors
identification
liver microsome
Lovastatin - analogs & derivatives
Lovastatin - metabolism
Male
Medical sciences
metabolite
Microsomes, Liver - metabolism
Pharmacology. Drug treatments
rat
Rats
Rats, Inbred Strains
sex difference
Sex Factors
Simvastatin
Rat
Metabolite
Liver
Rodentia
Sex
Male
NMR spectrometry
Microsome
Metabolism
In vitro
Vertebrata
Specificity
Mammalia
Animal
Antilipemic agent
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Summary:Simvastatin was more effectively metabolized by the liver microsomes of male rats than females. The sex difference appeared in the composition of the metabolites. Two male-specific metabolites were identified by NMR and mass spectrometry as 3"-hydroxy and 3', 3"-dihydroxy-Δ4', 5' derivatives of simvastatin.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.39.236