Preparatory activity and connectivity in dorsal anterior cingulate cortex for cognitive control

• Published in: NeuroImage (Orlando, Fla.) Vol. 57; no. 1; pp. 242 - 250
• Main Authors: Schulz, Kurt P., Bédard, Anne-Claude V., Czarnecki, Rosa, Fan, Jin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2011; Elsevier Limited
• Subjects: Adolescent; Adult; Attention deficit hyperactivity disorder; Brain Mapping; Cognition - physiology; Cognitive ability; Cortex (cingulate); Cortex (frontal); Cortex (motor); Cortex (somatosensory); Cues; Female; Functional magnetic resonance imaging; Go/no-go discrimination learning; Gyrus Cinguli - physiology; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Male; Neural Pathways - physiology; Neuroimaging; Operculum; Prefrontal cortex; Sensorimotor integration; Young Adult
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2011.04.023

Dorsal anterior cingulate cortex (dACC) is composed of functionally distinct subregions that may contribute to the top-down control of response selection and preparation. Multiple motor areas have been identified in dACC, including an anterior zone implicated in conflict monitoring and a caudal zone involved in movement execution. This study tested the involvement of a third cingulate area, the posterior zone of dACC, in the top-down control of response selection and preparation. Sixteen healthy young adults were scanned with event-related functional magnetic resonance imaging while performing a cued go/no-go task that was designed to minimize response conflicts. The activation and functional connectivity of dACC were tested with standard convolution models and psychophysiological interaction analyses, respectively. Ready cues that informed the direction of the impending response triggered preparatory neural activity in the posterior zone of dACC and strengthened functional connectivity with the anterior and caudal zones of dACC, as well as perigenual anterior cingulate cortex, frontal operculum, dorsolateral prefrontal cortex, sensory association cortices, and extra-pyramidal motor areas. The preparatory cues activated dACC above and beyond the general arousing effects common to cues despite negligible conflict in the go/no-go task. The integration of cognitive, sensorimotor, and incentive signals in dACC places the region in an ideal position to select and prepare appropriate behavioral responses to achieve higher-level goals. ► The dACC contributes to cognitive control functions beyond conflict monitoring. ► The dACC is engaged during the top-down control of response preparation. ► Response preparation increased connectivity between dACC and sensorimotor regions. ► Response preparation reduced the connectivity between the and default-mode network.