Pharmacological relevance of peripheral type benzodiazepine receptors on motor nerve and skeletal muscle
1 Effects of agonists and antagonists of peripheral and central benzodiazepine receptors (pBZR and cBZR) on neuromuscular transmission were studied in mouse isolated phrenic nerve‐diaphragm preparations. 2 Ro5–4864, a pBZR agonist, had no effect on the neuromuscular transmission but increased muscle...
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Published in | British journal of pharmacology Vol. 112; no. 1; pp. 257 - 261 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.05.1994
Nature Publishing |
Subjects | |
Online Access | Get full text |
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Summary: | 1
Effects of agonists and antagonists of peripheral and central benzodiazepine receptors (pBZR and cBZR) on neuromuscular transmission were studied in mouse isolated phrenic nerve‐diaphragm preparations.
2
Ro5–4864, a pBZR agonist, had no effect on the neuromuscular transmission but increased muscle contractility and antagonized the tetanic fade induced by neostigmine.
3
Ro5–4864 inhibited the regenerative tonic endplate depolarization caused by repetitive stimulation in the presence of neostigmine without affecting the amplitude and decay time of miniature and evoked single endplate potentials.
4
All the effects of Ro5–4864 were shared by PK11195, a pBZR antagonist, but not by clonazepam and flumazenil, a cBZR agonist and antagonist, respectively.
5
It is suggested that peripheral type benzodiazepine receptors modulate presynaptic function and muscle contraction. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0007-1188 1476-5381 |
DOI: | 10.1111/j.1476-5381.1994.tb13060.x |