妊娠高脂血症患者血浆血脂水平及LDL亚类分布变化

目的探讨妊娠高脂血症患者血浆血脂水平改变及低密度脂蛋白（LDL）亚类的分布特征。方法采集60例妊娠高脂血症患者（妊娠高脂血症组）和60例正常孕妇（正常孕妇组）的血浆,利用Lipoprint脂蛋白亚类分析系统检测血浆LDL亚类组成和含量。结果与正常孕妇组比较,妊娠高脂血症组血浆TC、TG、LDL-C水平明显高于正常孕妇组（P均〈0.01）。在60例妊娠高脂血症患者中,高甘油三酯血症为61.67%,高胆固醇血症为18.33%,混合型高脂血症为20.00%。与正常孕妇组比较,妊娠高脂血症组LDL 1、2浓度及LDL 1、2、3百分比低,LDL 4、5浓度及百分比高（P〈0.01或〈0.05）。结论妊...

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Published in山东医药 Vol. 56; no. 17; pp. 13 - 15
Main Author 张妮 贾连群 曲冬颖 吕美君 马艺鑫 杨关林
Format Magazine Article
LanguageChinese
Published 辽宁中医药大学中医脏象理论及应用教育部重点实验室,沈阳,110847%中国人民解放军第202医院 2016
Subjects
低密度脂蛋白亚类
妊娠高脂血症
血脂水平
血脂水平
低密度脂蛋白亚类
妊娠高脂血症
pregnancy hyperlipidemia
blood lipid level
low density lipoprotein subclasses
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Summary:目的探讨妊娠高脂血症患者血浆血脂水平改变及低密度脂蛋白（LDL）亚类的分布特征。方法采集60例妊娠高脂血症患者（妊娠高脂血症组）和60例正常孕妇（正常孕妇组）的血浆,利用Lipoprint脂蛋白亚类分析系统检测血浆LDL亚类组成和含量。结果与正常孕妇组比较,妊娠高脂血症组血浆TC、TG、LDL-C水平明显高于正常孕妇组（P均〈0.01）。在60例妊娠高脂血症患者中,高甘油三酯血症为61.67%,高胆固醇血症为18.33%,混合型高脂血症为20.00%。与正常孕妇组比较,妊娠高脂血症组LDL 1、2浓度及LDL 1、2、3百分比低,LDL 4、5浓度及百分比高（P〈0.01或〈0.05）。结论妊娠高脂血症患者中血脂水平均升高,高甘油三酯血症所占比例为最大,其血浆LDL亚类分布发生改变,即相对较大的颗粒浓度减少,相对较小的颗粒浓度升高。
Bibliography:ZHANG Ni;JIA Lianqun;QU Dongying;LYU Meijun;MA Yixin;YANG Guanlin（ 1 Liaoning University of Traditional Chinese Medicine, Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications, Shenyang 110847, China）
37-1156/R
pregnancy hyperlipidemia; blood lipid level; low density lipoprotein subclasses
Objective To discuss the changes in levels of blood plasma lipid and distribution characteristics of low density lipoprotein（ LDL） subclasses of pregnancy patients with hyperlipidemia. Methods The blood plasma was collected respectively from 60 pregnancy patients with hyperlipidemia（ pregnancy hyperlipidemia group） and 60 healthy pregnant women（ healthy pregnant woman group）. We used the Lipoprotein subclasses analysis system to detect the composition and content of LDL subclasses in the blood plasma. Results The levels of TC,TG and LDL-C in blood plasma were significantly higher in the pregnancy hyperlipidemia group than those of healthy pregnant woman group,and differences were statistical sig
ISSN:1002-266X
DOI:10.3969/j.issn.1002-266X.2016.17.004