精神分裂症患者前额叶的GABA及谷氨酸浓度异常——活体1H-MRS研究

背景：精神分裂症的病因及病理机制不明，传统的多巴胺(Dopamine，DA)假说不能完全解释其病理学及治疗学。谷氨酸（glutamate，Glu）及γ-氨基丁酸（γ-aminobutyric acid，GABA）假说认为精神分裂症患者脑内的Glu或GABA浓度异常。磁共振波谱(magneticresonancespectroscopy，MRS)技术发现精神分裂症谷氨酸类物质水平在前额叶腹内侧（ventromedial prefrontal cortex，vmPFC）（包括前扣带回）(anterior cingulate cortex，ACC)升高。目的:探讨谷氨酸系统（谷氨酸及γ-氨基丁酸）在...

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Published in上海精神医学 Vol. 29; no. 5; pp. 277 - 286
Main Author 陈天意;王颖婵;张建业;汪作为;许嘉乐;李瑶;杨志磊;刘登堂
Format Journal Article
LanguageChinese
Published 2017
Subjects
氨基丁酸;谷氨酸
精神分裂症;磁共振波谱;γ
精神分裂症
磁共振波谱
γ-氨基丁酸
γ-aminobutyric acid
magnetic resonance spectroscopy
谷氨酸
schizophrenia
glutamate
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Summary:背景：精神分裂症的病因及病理机制不明，传统的多巴胺(Dopamine，DA)假说不能完全解释其病理学及治疗学。谷氨酸（glutamate，Glu）及γ-氨基丁酸（γ-aminobutyric acid，GABA）假说认为精神分裂症患者脑内的Glu或GABA浓度异常。磁共振波谱(magneticresonancespectroscopy，MRS)技术发现精神分裂症谷氨酸类物质水平在前额叶腹内侧（ventromedial prefrontal cortex，vmPFC）（包括前扣带回）(anterior cingulate cortex，ACC)升高。目的:探讨谷氨酸系统（谷氨酸及γ-氨基丁酸）在精神分裂症原因学及病理机制中的作用。方法:24例未服药精神分裂症患者及24例性别、年龄及教育程度相配的健康志愿者入组，应用西门子MRI3T采集被试的磁共振波谱（magnetic resonance spectroscopy，MRS）数据，感兴趣区包括左侧前额叶背外侧（left dorsolateral prefrontal cortex，lDLPFC）、前额叶腹内侧（ventromedial prefrontal cortex，vmPFC）及前扣带回(anterior cingulate cortex，ACC)，运用LCModel软件分析了感兴趣区的γ-氨基丁酸（γ-aminobutyricacid，GABA）、谷氨酸（glutamate，Glu）、谷氨酰胺（glutamine，Gln）、氮乙酰天冬氨酸（N-acetylaspartate，NAA）及氮乙酰天冬氨酸谷氨酸（N-acetylaspartylglutamate，NAAG）等物质浓度。同时应用阳性与阴性症状量表（positive and negative Syndrome scale，PANSS）及临床总体印象量表（Clinical Global Impression Scale，CGI）评估患者的精神症状和疾病严重程度。
Bibliography:schizophrenia; magnetic resonance spectroscopy; γ-aminobutyric acid; glutamate
31-1564/R
Background:The etiology and pathomechanism of schizophrenia are unknown.The traditional dopamine(DA)hypothesis is unable to fully explain its pathology and therapeutics.The glutamate(Glu)andγ-aminobutyric acid(GABA)hypotheses suggest Glu or GABA concentrations are abnormal in the brains of patients with schizophrenia.Magnetic resonance spectroscopy(MRS)show glutamate level increases in the ventromedial prefrontal cortex(vmPFC)including the anterior cingulated cortex(ACC)in those with schizophrenia.Aims:To investigate the function of the glutamate system(glutamate andγ-aminobutyric acid)in the etiology and pathomechanism of schizophrenia.Methods:24drug na?ve patients with schizophrenia and24healthy volunteers were matched by gender,age,and educational level.The Siemens3T MRI system was used to collect the magnetic resonance spectroscopy(MRS)data of the subjects.The regions of interest included the left dorsolateral prefronta
ISSN:1002-0829