非酒精性脂肪性肝病的遗传易感性

非酒精性脂肪性肝病（NAFLD）是临床上最为常见的肝病之一,其病因及发病机制较为复杂。作为一种遗传-环境-代谢-应激相关性疾病,遗传因素在NAFLD的发病中起重要作用。为了认识NAFLD的发病机制中遗传因素的作用,探求NAFLD新的临床治疗靶点,归纳和整理了近年来与NAFLD相关的遗传易感基因,特别是对通过全基因组关联分析发现的基因,包括含patatin样磷酯酶域3、瘦素受体、脂联素、肿瘤坏死因子α等进行了论述。...

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Published in临床肝胆病杂志 Vol. 31; no. 7; pp. 1055 - 1058
Main Author 袁晨 程钰婷 姜曼 芦琳琳 辛永宁 宣世英
Format Journal Article
LanguageChinese
Published 青岛市市立医院消化内二科,山东青岛,266021%青岛市消化疾病重点实验室,山东青岛,266021%青岛市市立医院消化内二科,山东青岛266021 2015
青岛市消化疾病重点实验室,山东青岛266021
Subjects
多态性,单核苷酸
疾病遗传易感性
脂肪肝
脂肪肝
fatty liver
polymorphism,single nucleotide
genetic predisposition to disease
多态性,单核苷酸
疾病遗传易感性
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ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2015.07.014

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Summary:非酒精性脂肪性肝病（NAFLD）是临床上最为常见的肝病之一,其病因及发病机制较为复杂。作为一种遗传-环境-代谢-应激相关性疾病,遗传因素在NAFLD的发病中起重要作用。为了认识NAFLD的发病机制中遗传因素的作用,探求NAFLD新的临床治疗靶点,归纳和整理了近年来与NAFLD相关的遗传易感基因,特别是对通过全基因组关联分析发现的基因,包括含patatin样磷酯酶域3、瘦素受体、脂联素、肿瘤坏死因子α等进行了论述。
Bibliography:YUAN Chert, CHENG Yuting, JIANG Man, et al. （ Second Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, Shandong 266021, China）
Non- alcoholic fatty liver disease（ NAFLD） is one of the most common liver diseases,with complicated etiology and pathogenesis. As a heredity- environment- metabolism- stress disease,the genetic factors play an important role in the pathogenesis of NAFLD. In order to identify the role of genetic factors in the pathogenesis of NAFLD and to find out new clinical therapeutic targets,the present review summarizes the susceptibility genes of NAFLD,especially those identified by genome- wide association study,including the genes of patatin- like phospholipase domain- containing 3,leptin receptor,adiponectin,and tumor necrosis factor- ɑ.
fatty liver; genetic predisposition to disease; polymorphism; single nucleotide
22-1108/R
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2015.07.014