循环miRNA在肝胆疾病诊断中的研究进展

R575; 微小核糖核酸（microRNA），简称miRNA，参与着生命活动的病理生理过程，在人体血清、血浆等体液中存在丰富而稳定的循环miRNA。简述了循环miRNA与病毒性肝炎、肝纤维化、肝硬化、肝癌、药物性肝炎等肝胆疾病或疾病不同阶段的表达谱存在明显差异性，其中一些循环miRNA可作为相关疾病早期诊断、病情进展和预后评估的新型无创性生物标志。本文就循环miRNA在肝胆疾病诊断研究中的最新进展作一综述。...

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Published in临床肝胆病杂志 Vol. 30; no. 9; pp. 965 - 966
Main Author 彭小芳 刘海英
Format Journal Article
LanguageChinese
Published 广州医科大学附属广州市妇女儿童医疗中心 临床检验部,广州,510180 2014
Subjects
微RNAs
综述
肝疾病
胆道疾病
诊断
microRNAs
胆道疾病
诊断
biliary tract diseases
肝疾病
review
diagnosis
liver diseases
综述
微RNAs
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Summary:R575; 微小核糖核酸（microRNA），简称miRNA，参与着生命活动的病理生理过程，在人体血清、血浆等体液中存在丰富而稳定的循环miRNA。简述了循环miRNA与病毒性肝炎、肝纤维化、肝硬化、肝癌、药物性肝炎等肝胆疾病或疾病不同阶段的表达谱存在明显差异性，其中一些循环miRNA可作为相关疾病早期诊断、病情进展和预后评估的新型无创性生物标志。本文就循环miRNA在肝胆疾病诊断研究中的最新进展作一综述。
Bibliography:MicroRNAs（ miRNAs） are involved in the pathological and physiological process of life activities,and some of them exist stably and abundantly in serum,plasma,and other body fluids. Previous studies have indicated that there are significant differences in the expression patterns of circulating miRNAs between patients with viral hepatitis,liver fibrosis,liver cirrhosis,hepatocellular carcinoma,drug- induced hepatitis,and other hepatobiliary diseases at different disease stages. Among these circulating miRNAs,some can act as novel noninvasive biomarkers for the early diagnosis,disease progression,and prognostic evaluation of related diseases. The latest research advances in circulating miRNAs for the diagnosis of hepatobiliary diseases are reviewed.
liver diseases; biliary tract diseases; microRNAs; diagnosis; review
PENG Xiaofang, LIU Haiying. （ Clinical Laboratory, Guangzhou Women and Children~ Medical Center Affiliated to Guangzhou Medical Uni- versity, Guangzhou 510180, China）
22-1108/R
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2014.09.032