Mitochondrial Role in Stemness and Differentiation of Hematopoietic Stem Cells

Quiescent and self-renewing hematopoietic stem cells (HSCs) rely on glycolysis rather than on mitochondrial oxidative phosphorylation (OxPHOS) for energy production. HSC reliance on glycolysis is considered an adaptation to the hypoxic environment of the bone marrow (BM) and reflects the low energet...

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Published inStem cells international Vol. 2019; no. 2019; pp. 1 - 10
Main Authors Papa, Luena, Hoffman, Ronald, Djedaini, Mansour
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2019
Hindawi
Hindawi Limited
Subjects
Blood
Bone marrow
Cell cycle
Cell self-renewal
Decisions
Differentiation
Energy
Gene expression
Glycolysis
Hematopoiesis
Hematopoietic stem cells
Homeostasis
Hypoxia
Kinases
Metabolism
Mitochondria
Mitochondrial DNA
Oxidative phosphorylation
Oxidative stress
Phosphorylation
Review
Rewiring
Stem cells
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Summary:Quiescent and self-renewing hematopoietic stem cells (HSCs) rely on glycolysis rather than on mitochondrial oxidative phosphorylation (OxPHOS) for energy production. HSC reliance on glycolysis is considered an adaptation to the hypoxic environment of the bone marrow (BM) and reflects the low energetic demands of HSCs. Metabolic rewiring from glycolysis to mitochondrial-based energy generation accompanies HSC differentiation and lineage commitment. Recent evidence, however, highlights that alterations in mitochondrial metabolism and activity are not simply passive consequences but active drivers of HSC fate decisions. Modulation of mitochondrial activity and metabolism is therefore critical for maintaining the self-renewal potential of primitive HSCs and might be beneficial for ex vivo expansion of transplantable HSCs. In this review, we emphasize recent advances in the emerging role of mitochondria in hematopoiesis, cellular reprograming, and HSC fate decisions.
Bibliography:ObjectType-Article-2
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Guest Editor: Viviana Moresi
ISSN:1687-966X
1687-9678
DOI:10.1155/2019/4067162