Protective effect of Carthamus tinctorius L. seed on oxidative stress and cognitive impairment induced by chronic alcohol consumption in mice

• Published in: Food science and biotechnology Vol. 27; no. 5; pp. 1475 - 1484
• Main Authors: Choi, Seung Hak, Lee, Ah Young, Park, Chan Hum, Shin, Yu Su, Cho, Eun Ju
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.10.2018; Springer Nature B.V; 한국식품과학회
• Subjects: Acetaldehyde; Acetylcholinesterase; alcohol abuse; alcohol drinking; Alcohol use; Alcoholic beverages; Alcohols; Apoptosis; brain; Brain damage; Brain injury; Carthamus tinctorius; Chemistry; Chemistry and Materials Science; cognition; Cognitive ability; cognitive disorders; Dementia; Dementia disorders; enzyme activity; Food Science; inflammation; Kidneys; Lipid peroxidation; Lipids; Liver; memory; Mice; neurons; Nitric oxide; Nutrition; Object recognition; Oral administration; Oxidative stress; Pattern recognition; Peroxidation; protective effect; 식품과학; Oxidative stress; Alcohol; Cognition; L. seed; Dementia; Carthamus tinctorius L. seed
• ISSN: 1226-7708; 2092-6456; 2092-6456
• DOI: 10.1007/s10068-018-0472-4

Chronic alcohol consumption induces damage to the brain that can cause various forms of dementia. An abundance of acetaldehyde is produced by excessive alcohol consumption and accumulates in the body to induce oxidative stress, apoptosis, and inflammation in neuronal cells, which results in learning and cognitive decline. In the present study, C57BL/N mice were orally administered alcohol (16%) and Carthamus tinctorius L. seed (CTS) (100 and 200 mg/kg/day). Behavioral experiments showed that memory and cognitive abilities were significantly higher in the CTS groups than the alcohol-treated control group in the T-maze test, novel object recognition test, and Morris water maze test. In addition, CTS inhibited alcohol-induced lipid peroxidation and nitric oxide production in the brain, kidney, and liver. Moreover, alcohol increased acetylcholinesterase activity in the brain, but this was significantly decreased by the administration of CTS. Therefore, CTS may play role in the prevention of alcohol-related dementia.