DNMT3B7 expression related to MENT expression and its promoter methylation in human lymphomas

• Published in: Leukemia research Vol. 37; no. 12; pp. 1662 - 1667
• Main Authors: Alkebsi, Lobna, Handa, Hiroshi, Sasaki, Yoshiko, Osaki, Yohei, Yanagisawa, Kunio, Ogawa, Yoshiaki, Yokohama, Akihiko, Hattori, Hikaru, Koiso, Hiromi, Saitoh, Takayuki, Mitsui, Takeki, Tsukamoto, Norifumi, Nojima, Yoshihisa, Murakami, Hirokazu
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2013
• Subjects: Alternative Splicing - genetics; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases - genetics; DNA Methylation - physiology; DNA Methyltransferase 3A; DNA Methyltransferase 3B; DNMT3B7; Gene Expression Regulation, Enzymologic - physiology; Gene Expression Regulation, Neoplastic; Hematology, Oncology and Palliative Medicine; Human lymphoma; Humans; Isoenzymes - genetics; Leukocytes, Mononuclear - metabolism; Leukocytes, Mononuclear - pathology; Lymphoma - genetics; Lymphoma - pathology; MENT; Neoplasm Proteins - genetics; Promoter Regions, Genetic; Proto-Oncogene Mas; Proto-Oncogenes - genetics; Human lymphoma; DNMT3B7; MENT
• ISSN: 0145-2126; 1873-5835
• DOI: 10.1016/j.leukres.2013.09.014

Abstract DNA methyltransferase (DNMT) 3B7 is the most expressed DNMT3B splice variant. It was reported that the loss of DNMT3B function led to overexpression of the ME thylated in N ormal T hymocyes ( MENT ) and accelerated mouse lymphomagenesis. We investigated the DNMT3B7 expression and its relationship to MENT expression and promoter methylation in human lymphomas. DNMT3B7 and MENT expression were significantly ( p < 0.0001, p < 0.01) higher in lymphomas than in non-malignant. Expression of DNMT3B7 and MENT were associated with MENT promoter hypomethylation. DNMT3B7 overexpression might interfere with the normal DNA methylation mechanism required for silencing the MENT proto-oncogene, and may accelerate human lymphomagenesis.