Antigenic homology among coronaviruses related to transmissible gastroenteritis virus

• Published in: Virology (New York, N.Y.) Vol. 174; no. 2; pp. 410 - 417
• Main Authors: Sánchez, Carlos M., Jiménez, Gustavo, Laviada, María D., Correa, Isabel, Suñé, Carlos, Bullido, María J., Gebauer, Fátima, Smerdou, Cristian, Callebaut, Paul, Escribano, JoséM., Enjuanes, Luis
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.02.1990; Elsevier; Published by Elsevier Inc
• Subjects: Animals; Antibodies, Monoclonal; ANTICORPS MONOCLONAL; ANTICUERPOS MONOCLONALES; ANTIGENE; ANTIGENOS; ANTIGENS; Antigens, Viral - analysis; Biological and medical sciences; CHIEN; CONTENIDO PROTEICO; CORONAVIRIDAE; Coronaviridae - classification; Coronaviridae - genetics; Coronaviridae - immunology; DOGS; Epitopes - analysis; FELINE PERITONITIS VIRUS; Fundamental and applied biological sciences. Psychology; GENERO HUMANO; GENOMAS; GENOME; GENOMES; GENRE HUMAIN; MANKIND; Microbiology; MONOCLONAL ANTIBODIES; Morphology, structure, chemical composition, physicochemical properties; PERRO; PROTEIN CONTENT; Swine; TENEUR EN PROTEINES; TRANSMISSIBLE GASTROENTERITIS VIRUS; Transmissible gastroenteritis virus - immunology; Viral Structural Proteins - analysis; Virology; VIRUS GASTROENTERITE DU PORC; VIRUS GASTROENTERITIS TRANSMISIBLE; Binding; Antigenic relationship; Antigenic determinant; Taxonomy; Antigen antibody reaction; Homology; Monoclonal antibody; Porcine transmissible gastroenteritis virus; Virus; Antigen; Coronavirus; Neutralization test; Radioimmunoassay; Coronaviridae
• ISSN: 0042-6822; 1096-0341
• DOI: 10.1016/0042-6822(90)90094-8

The antigenic homology of 26 coronavirus isolates, of which 22 were antigenically related to transmissible gastroenteritis virus (TGEV), was determined with 42 monoclonal antibodies. Type, group, and interspecies specific epitopes were defined. Two group specific MAbs distinguished the enteric TGEV isolates from the respiratory variants. An antigenic subsite involved in neutralization was conserved in porcine, feline, and canine coronavirus. The classification of the human coronavirus 229E in a taxonomic cluster distinct from TGEV group is suggested.