In Vitro and in Vivo Antiviral Activity of Mizoribine Against Foot-And-Mouth Disease Virus

• Published in: Molecules (Basel, Switzerland) Vol. 24; no. 9; p. 1723
• Main Authors: Li, Shi-Fang, Gong, Mei-Jiao, Sun, Yue-Feng, Shao, Jun-Jun, Zhang, Yong-Guang, Chang, Hui-Yun
• Format: Journal Article Web Resource
• Language: English
• Published: Switzerland MDPI AG 03.05.2019; Multidisciplinary Digital Publishing Institute (MDPI); MDPI
• Subjects: Animals; antiviral; Antiviral Agents - administration & dosage; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Antiviral drugs; Cell Line; Communication; Cytotoxicity; Dehydrogenases; Disease Outbreaks; Drug dosages; Foot & mouth disease; foot-and-mouth disease; Foot-and-Mouth Disease - drug therapy; Foot-and-Mouth Disease - epidemiology; Foot-and-Mouth Disease - virology; foot-and-mouth disease virus; Foot-and-Mouth Disease Virus - drug effects; Foot-and-Mouth Disease Virus - physiology; Gene Expression Regulation, Viral - drug effects; in vivo; Infections; Kinases; Life sciences; Mice; mizoribine; Médecine vétérinaire & santé animale; Proteins; Ribonucleosides - administration & dosage; Ribonucleosides - chemistry; Ribonucleosides - pharmacology; Sciences du vivant; Swine; Vaccines; Veterinary medicine & animal health; Viral infections; Viral Proteins - metabolism; Virus Replication - drug effects; Viruses; foot-and-mouth disease virus; foot-and-mouth disease; in vivo; mizoribine; antiviral
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules24091723

Foot-and-mouth disease (FMD) is a highly contagious viral disease of cloven-hoofed animals, which has significant economic consequences in affected countries. As the currently available vaccines against FMD provide no protection until 4–7 days post-vaccination, the only alternative method to control the spread of FMD virus (FMDV) during outbreaks is the application of antiviral agents. Hence, it is important to identify effective antiviral agents against FMDV infection. In this study, we found that mizoribine has potent antiviral activity against FMDV replication in IBRS-2 cells. A time-of-drug-addition assay demonstrated that mizoribine functions at the early stage of replication. Moreover, mizoribine also showed antiviral effect on FMDV in vivo. In summary, these results revealed that mizoribine could be a potential antiviral drug against FMDV.