The Long Terminal Repeat Sequences of a Novel Human Endogenous Retrovirus
The complete nucleotide sequence of both the 5$^{\prime}$ and 3$^{\prime}$ long terminal repeats (LTR's) has been determined for a human endogenous retroviral genome. These sequences are 593 and 590 nucleotides long and have diverged from one another by 8.8 percent. The LTR's resemble thos...
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Published in | Science (American Association for the Advancement of Science) Vol. 226; no. 4679; pp. 1204 - 1206 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Washington, DC
The American Association for the Advancement of Science
07.12.1984
American Association for the Advancement of Science |
Subjects | |
Online Access | Get full text |
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Summary: | The complete nucleotide sequence of both the 5$^{\prime}$ and 3$^{\prime}$ long terminal repeats (LTR's) has been determined for a human endogenous retroviral genome. These sequences are 593 and 590 nucleotides long and have diverged from one another by 8.8 percent. The LTR's resemble those of functional mammalian type C retroviruses in length and in the presence and location of eukaryotic promoter sequences. The 5$^{\prime}$ LTR is followed by a presumptive primer binding site unlike that of any known mammalian type C retrovirus, exhibiting 17 out of 18 nucleotides complementary to arginine transfer RNA rather than proline transfer RNA. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0036-8075 1095-9203 |
DOI: | 10.1126/science.6505687 |