The Long Terminal Repeat Sequences of a Novel Human Endogenous Retrovirus

• Published in: Science (American Association for the Advancement of Science) Vol. 226; no. 4679; pp. 1204 - 1206
• Main Authors: O'Connell, Catherine D., Cohen, Maurice
• Format: Journal Article
• Language: English
• Published: Washington, DC The American Association for the Advancement of Science 07.12.1984; American Association for the Advancement of Science
• Subjects: Base Sequence; Binding sites; Biological and medical sciences; Cancer; Cancer research; Causes of; DNA, Recombinant; Fundamental and applied biological sciences. Psychology; Gene expression; Genes, Regulator; Genomes; Humans; Messenger RNA; Microbiology; Morphology, structure, chemical composition, physicochemical properties; Nucleotide sequences; Nucleotides; Oncology, Experimental; Operon; Promoter regions; Proviruses; Repetitive Sequences, Nucleic Acid; Retroviridae; Retroviridae - genetics; Retroviruses; RNA, Viral - analysis; Transfer RNA; Tumors; Viral RNA; Virology; Human origin; 5' terminal-Sequence; Oncovirinae; 3' terminal-Sequence; Retroviridae; Primary structure; Molecular size; Flanking sequence; Terminal repeated sequence; Provirus; Mammalian type C oncovirus; Virus; Endogenous; Transcription promotor; Type C oncovirus; DNA; Comparative study
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.6505687

The complete nucleotide sequence of both the 5$^{\prime}$ and 3$^{\prime}$ long terminal repeats (LTR's) has been determined for a human endogenous retroviral genome. These sequences are 593 and 590 nucleotides long and have diverged from one another by 8.8 percent. The LTR's resemble those of functional mammalian type C retroviruses in length and in the presence and location of eukaryotic promoter sequences. The 5$^{\prime}$ LTR is followed by a presumptive primer binding site unlike that of any known mammalian type C retrovirus, exhibiting 17 out of 18 nucleotides complementary to arginine transfer RNA rather than proline transfer RNA.