Anti-obesity effects of a mixture of thiamin, arginine, caffeine, and citric acid in non-insulin dependent diabetic KK mice

• Published in: Journal of Nutritional Science and Vitaminology Vol. 49; no. 1; pp. 56 - 63
• Main Authors: Muroyama, K. (Takeda Food Products Ltd., Itami, Hyogo (Japan)), Murosaki, S, Yamamoto, Y, Odaka, H, Chung, H.C, Miyoshi, M
• Format: Journal Article
• Language: English
• Published: Tokyo Center for Academic Publications Japan 2003
• Subjects: Adipose Tissue - pathology; Animals; Anti-Obesity Agents - administration & dosage; ARGININE; Arginine - administration & dosage; Biological and medical sciences; CAFFEINE; Caffeine - administration & dosage; CITRIC ACID; Citric Acid - administration & dosage; DIABETES; Diabetes Mellitus, Type 2 - complications; Diet; Dietary Supplements; Energy Intake; Insulin - blood; lipid metabolism; Lipids - biosynthesis; Liver - chemistry; Liver - drug effects; Liver - metabolism; Medical sciences; Metabolic diseases; MICE; Obesity; Organ Size - drug effects; OVERWEIGHT; Tea; THIAMIN; Thiamine - administration & dosage; Triglycerides - analysis; Endocrinopathy; Animal model; Obesity; Rodentia; Nutrition disorder; lipid metabolism; B-Vitamins; Non insulin dependent diabetes; mice; Citric acid; Feeding; Vertebrata; Mammalia; Arginine; Mouse; Animal; Nutritional status; Thiamine; Caffeine; Low calorie diet
• ISSN: 0301-4800; 1881-7742
• DOI: 10.3177/jnsv.49.56

Anti-obesity effects of a mixture of thiamin, arginine, caffeine, and citric acid (TACO) were investigated in non-insulin dependent diabetic KK mice. Feeding of either arginine or caffeine significantly suppressed an increase in hepatic lipid contents in fasted-refed KK mice. In addition, each component admixed with a low-calorie diet effectively reduced adipose tissue weight in KK mice previously fed a high-calorie diet. The decrease in adipose tissue weight was greater with a mixture of arginine and caffeine, and much greater with TACC than with arginine or caffeine alone. Moreover, plasma insulin concentration was significantly lower in mice fed TACC than in control mice. The anti-obesity effects of TACC were also shown when it was supplemented with a tea beverage. Adipose tissue weight, hepatic triglyceride contents, and plasma insulin concentration were significantly lower in mice given TACC-supplemented tea than in control mice. These results suggest that TACC is effective in reducing adipose tissue mass as well as improving disorders in lipid metabolism