Intracerebroventricular administration of HIV-1 Tat induces brain cytokine and indoleamine 2,3-dioxygenase expression: A possible mechanism for AIDS comorbid depression

Highlight ► HIV Tat-induced neuroinflammation is associated with depressive-like behavior.

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Bibliographic Details
Published inBrain, behavior, and immunity Vol. 25; no. 8; pp. 1569 - 1575
Main Authors Lawson, Marcus A, Kelley, Keith W, Dantzer, Robert
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.11.2011
Subjects
Acquired Immunodeficiency Syndrome - complications
Acquired Immunodeficiency Syndrome - psychology
Allergy and Immunology
Anhedonia - drug effects
Animals
Brain - drug effects
Brain - enzymology
Brain Chemistry - drug effects
Cytokines
Cytokines - biosynthesis
Depression
Depressive Disorder - etiology
Depressive Disorder - psychology
Exploratory Behavior
Food Preferences - drug effects
Human immunodeficiency virus
Human immunodeficiency virus 1
Illness Behavior
Indoleamine 2,3-dioxygenase
Indoleamine-Pyrrole 2,3,-Dioxygenase - biosynthesis
Injections, Intraventricular
Macrophage Activation - drug effects
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Psychiatry
Real-Time Polymerase Chain Reaction
RNA, Messenger - biosynthesis
Social Behavior
Sucrose
Swimming - psychology
Tat
tat Gene Products, Human Immunodeficiency Virus - administration & dosage
tat Gene Products, Human Immunodeficiency Virus - pharmacology
Indoleamine 2,3-dioxygenase
Depression
Cytokines
Tat
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Summary:Highlight ► HIV Tat-induced neuroinflammation is associated with depressive-like behavior.
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ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2011.05.006