Three-Dimensional Modeling of the Dynamics of Therapeutic Ultrasound Contrast Agents

Abstract A 3-D thick-shell contrast agent dynamics model was developed by coupling a finite volume Navier-Stokes solver and a potential boundary element method flow solver to simulate the dynamics of thick-shelled contrast agents subjected to pressure waves. The 3-D model was validated using a spher...

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Published inUltrasound in medicine & biology Vol. 36; no. 12; pp. 2065 - 2079
Main Authors Hsiao, Chao-Tsung, Lu, Xiaozhen, Chahine, Georges
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.12.2010
Elsevier
Subjects
Biological and medical sciences
Bubble dynamics
Contrast Media
Contrast media. Radiopharmaceuticals
Drug delivery
Encapsulated microbubble
Medical sciences
Microbubbles
Models, Theoretical
Numerical modeling
Pharmacology. Drug treatments
Radiology
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Ultrasonic Therapy
Ultrasonics
Ultrasound contrast agent
Viscosity
Numerical modeling
Ultrasound contrast agent
Bubble dynamics
Drug delivery
Encapsulated microbubble
Encapsulation
Drug
Microbubble
Ultrasonic treatment
Instrumentation therapy
Drug carrier
Modeling
Three dimensional model
Ultrasound
Contrast media
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Summary:Abstract A 3-D thick-shell contrast agent dynamics model was developed by coupling a finite volume Navier-Stokes solver and a potential boundary element method flow solver to simulate the dynamics of thick-shelled contrast agents subjected to pressure waves. The 3-D model was validated using a spherical thick-shell model validated by experimental observations. We then used this model to study shell break-up during nonspherical deformations resulting from multiple contrast agent interaction or the presence of a nearby solid wall. Our simulations indicate that the thick viscous shell resists the contrast agent from forming a re-entrant jet, as normally observed for an air bubble oscillating near a solid wall. Instead, the shell thickness varies significantly from location to location during the dynamics, and this could lead to shell break-up caused by local shell thinning and stretching. (E-mail: ctsung@dynaflow-inc.com )
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ISSN:0301-5629
1879-291X
DOI:10.1016/j.ultrasmedbio.2010.08.022